摘要
目的探讨人外周血白细胞介素21(interleukin-21,IL-21)与卵巢早衰(premature ovarian failure,POF)及卵巢功能减退(decreased ovarian reserve,DOR)的发病是否相关。方法收集POF患者25例、DOR患者14例以及健康体检的育龄女性18例作为对照,采用放射免疫法检测血清IL-21水平,并与其他实验室指标进行相关性分析。结果 POF组和DOR组患者的血清IL-21水平较对照组明显升高,差异有统计学意义(F=4.971,P=0.010),POF组和DOR组患者的血清IL-21水平近似,差异无统计学意义(P>0.05)。IL-21分别与促卵泡激素(follicle stimulating hormone,FSH)、抗苗勒管激素(anti-miillerian hormone,AMH)呈正相关(r=0.389,P=0.003;r=0.275,P=0.040),IL-21分别与雌二醇(estradiol,E2)、平均卵巢体积(mena ovarian volume,MOV)呈负相关(r=-0.377,P=0.004;r=-0.271,P=0.042)。结论血清IL-21在POF患者中升高,而且在DOR患者中明显升高,并与卵巢储备功能相关,提示IL-21可能参与早期POF的发病过程,可望成为防治POF的新途径。
This study aims to confirm whether and how serum interleukin-21 （IL-21） associates with the pathology of premature ovarian failure （POF） and decreased ovarian reserve （DOR）. With radioimmunoassay, we detected IL-21 level in the serum of healthy controls and patients with POF or DOR. Compared to control group, the serum IL-21 level of POF group and DOR group were significantly higher （F=4.971 ,P=0.010）. There was no difference about the serum IL-21 level between POF group and DOR group （P〉0.05）. A positive correlation existed among IL-21 and FSH （follicle stimulating hormone）, AMH （anti-miillerian hormone）, respectively. While a negative correlation existed among IL-21 and E2 （estradiol）, MOV （mean ovarian volume）, respectively. From these resuhs, the increase of serum IL-21 in POI patients, especially DOR patients may indicate the cytokine highly correlates to POI. Intervention of IL-21 may be a potential therapeutic option for POI.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2015年第5期458-460,共3页
Immunological Journal
基金
广州市科技计划项目(11C32120702)
广东省科技计划项目(2012B031800123)
广东高校优秀青年创新人才培养计划项目育苗工程(2012LYM_0034)
关键词
IL-21
卵巢储备功能
卵巢早衰
Interleukin-21
Ovarian reserve
Premature ovarian failure
作者简介
通信作者：何援利，E-mail：heyuanli310@163．com
