摘要
自身抗体的存在及T细胞介导的炎症反应共同促进卵巢早衰的发生。卵巢早衰患者体内多有如抗卵巢抗体等器官特异性抗体和抗类固醇细胞及其酶抗体等自身抗体,淋巴细胞亚群比例失衡。雌激素及中医药治疗是常用的方法,但疗效均不理想。本文对近年有关卵巢早衰的免疫学方面的研究进行综述,旨在为进一步研究卵巢早衰的发病机制,制定高危人群及早期诊断标准提供参考。
Autoantibody and T cell-mediated inflammatory reaction are thought to play an important role in the premature ovarian failure (POF). Organ-specific autoantibodies such as antiovarian antibody and other autoantibodies such as steroid-producing cell autoantibodies and the antibodies to steroidogenic enzymes are often detected in POF patients, and the proportion of lymphocyte subsets in these patients is abnormal. Estrogen and Chinese herbs are usually used to treat POF, but the results are not satisfied. This article reviewed the recent research progress in the immunological features of POF in order to provide some ideas for the further study of its pathogenesis and for the identification of high-risk group and early diagnosis.
出处
《生殖医学杂志》
CAS
2005年第2期120-124,共5页
Journal of Reproductive Medicine
基金
广东省中医药局立项科研课题(403021)
国家自然科学基金项目(30400607)
关键词
卵巢早衰
自身抗体
淋巴细胞亚群
分子免疫
Premature ovarian failure
Autoantibody
Lymphocyte subsets
Molecular (immunity)
