炎症标志物血清降钙素原和超敏C反应蛋白与多囊卵巢综合征相关因素研究被引量：9

Correlation between inflammatory markers of serum procalcitonin & hs-CRP and related indicators of polycystic ovary syndrome

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摘要目的通过研究多囊卵巢综合征(PCOS)患者炎症标志物血清降钙素原和超敏C反应蛋白(hs-CRP)的水平,探讨炎症标志物血清降钙素原、hs-CRP与PCOS的有关指标相关性。方法选择40例PCOS患者为病例组,同期来院就诊的40例不孕不育症患者为对照组。并根据体重指数(BMI)水平分为BMI≥25kg/m2的PCOS患者为PCOS肥胖组(A组,20例),BMI<25kg/m2的PCOS患者为PCOS非肥胖组(B组,20例);BMI≥25kg/m2的不孕不育患者为非PCOS肥胖组(C组,20例),BMI<25kg/m2的不孕不育患者为非PCOS非肥胖组(D组,20例)。四组研究对象入院后采集静脉血,进行血清降钙素原、hs-CRP、空腹胰岛素(FIN)、血糖、性激素、性激素结合蛋白(SHBG)的检测;PCOS组与对照组均数间比较及PCOS组胖瘦组之间比较采用两独立样本t检验,各因素间关系采用Spearman相关性分析。结果血清降钙素原与PCOS患者以下指标如BMI、腰臀比(WHR)、稳态胰岛素评价指数(HOMA-IR)、低密度脂蛋白胆固醇(LDL-C)、FIN、卵泡刺激素(FSH)、黄体生成素(LH)、睾酮(T)、卵泡(Fc)总数、左卵巢Fc个数、右卵巢Fc个数、SHBG等均有相关性(P<0.05)。hs-CRP与PCOS患者以下指标:BMI、WHR、HOMA-IR,FIN、FSH、LH、T、雌二醇(E2)、SHBG等均有相关性(P<0.05)。结论炎症标志物血清降钙素原、hs-CRP与PCOS具有相关性,但炎症介质在PCOS中的作用机制尚需研究,以期阐明其相关机制。 Objective： To explore the correlation between the inflammatory markers of procalcitonin hypersensitive C-reactive protein（hs-CRP）and related indicators of polycystic ovary syndrome（PCOS）.Methods：Forty patients with PCOS were selected in the observe group,and 40 infertile patients in the control group.The patients were subdivided to 4groups according to BMI levels：the obese（BMI≥25kg/m^2）patients with PCOS in group A（n=20）,the non-obese（BMI〈25kg/m^2）patients with PCOS in group B（n=20）,the obese（BMI≥25kg/m^2）patients without PCOS in group C（n=20）,and the non-obese（BMI25kg/m^2）patients without PCOS in group D（n=20）.The serum samples were collected from the patients of the four groups for detecting procalcitonin,hs-CRP,fasting insulin（FIN）and blood glucose,hormone levels and sex hormone binding globulin（SHBG）.The parameter were analyzed and compared among the four groups by using two independent samples t-test and Spearman correlation analysis.Results：In the patients with PCOS,the serum calcitonin were correlated with BMI,waist-to-hip ratio（WHR）,Homeostasis model assessment for insulin resistance（HOMA-IR）LDL-C,FIN,FSH,LH,T,E2,total number of follicles,number of follicles in left or right ovary,SHBG（P〈0.05）.The hs-CRP were correlated with BMI,WHR,HOMA-IR,FIN,FSH,LH,T,E2,SHBG（P〈0.05）.Conclusions： Serum inflammatory markers procalcitonin hs-CRP are correlated with some parameter of the patients with PCOS,but the mechanism for inflammatory mediators in the pathogenesis of PCOS is not clear,which need further investigation

作者王汝琴陈倩陈晓军梁玉杰鲍淑静

机构地区浙江省乐清市人民医院妇产科浙江省乐清市人民医院检验科

出处《生殖医学杂志》 CAS 2015年第5期357-362,共6页 Journal of Reproductive Medicine

基金温州市2014年度医药卫生科学研究项目计划(2014B48)

关键词血清降钙素原超敏C反应蛋白多囊卵巢综合征 Serum procalcitonin Hypersensitive C-reactive protein Polycystic ovary syndrome

分类号 R [医药卫生]

作者简介王汝琴，女，浙江乐清人，大学，主治医师，妇产科专业．

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