摘要
目的探讨血清降钙素原与急性心肌梗死患者炎症反应的关系。方法收集80例AMI患者(AMI组),稳定性心绞痛患者60例(SAP组)及冠脉动脉造影正常的患者50例(对照组)。比较各组血清的hs-CRP、PCT,并分析两者在AMI中的诊断效能及两者的关系。结果AMI组、SAP组血清hs-CRP、PCT水平均高于对照组,差异具有统计学意义(P<0.05),AMI组血清hs-CRP、PCT水平均高于SAP组,差异具有统计学意义(P<0.05)。PCT对AMI炎症反应诊断的敏感度、特异度分别为80.0%、80.6%;hs-CRP分别为75.0%、69.4%。Logistic回归分析显示,PCT、hs-CRP为AMI的独立危险因素(P<0.001)。AMI组血清PCT与hs-CRP呈正的相关性(r=0.476,P<0.05)。结论血清PCT水平高低与AMI存在显著的关系,联合检测PCT和hs-CR利于AMI早期诊断与严重程度的评估。
Objective To investigate the relationship between serum calcitonin and inflammatory response in patients with acute myocardial infarction.Methods 80 patients with AMI(AMI group),60 patients with stable angina pectoris(SAP group)and 50 patients with normal coronary arteriography(control group)were collected.The serum levels of hs-CRP and PCT were compared and the diagnostic efficacy and the relationship between the two in AMI were analyzed.Results The serum levels of hs-CRP and PCT in AMI group and SAP group were significantly higher than those in the control group(P<0.05),and the level of serum hs-CRP and PCT in group AMI was significantly higher than that in group SAP(P<0.05).The sensitivity and specificity of PCT for the diagnosis of AMI inflammatory reaction were 80.0%and 80.6%respectively,and 75.0%and 69.4%for hs-CRP respectively.Logistic regression analysis showed that PCT and hs-CRP were independent risk factors of AMI(P<0.001).There was a positive correlation between serum PCT and hs-CRP in AMI group(r=0.476,P<0.05).Conclusion There is a significant relationship between the level of serum PCT and the level of AMI.The combined detection of PCT and hs-CR is beneficial to the early diagnosis and severity of AMI.
作者
张涛
ZHANG Tao(Cardiology Department,Ningjin County People's Hospital,Ningjin Shandong 253400,China)
出处
《中国继续医学教育》
2018年第10期94-95,共2页
China Continuing Medical Education
关键词
降钙素原
急性心肌梗死
心肌钙蛋白
炎症反应
calcitonin
acute myocardial infarction
myocardial calcinin
inflammatory reaction
