摘要
目的宫腔镜下宫腔粘连分解术(transcervical resection of adhensions,TCRA)可有效治疗宫腔粘连,但TCRA术后宫腔粘连复发是影响疗效的主要问题。因此TCRA术后如何防止宫腔再粘连是本课题研究的目的。本课题通过研究宫腔粘连患者治疗前后血清及子宫内膜中血管内皮生长因子(VEGF)表达变化,从而探讨中药补肾活血周期治疗在宫腔镜术后再粘连预防的作用机制。方法选择因宫腔粘连在我院行宫腔镜下宫腔粘连分解术(TCRA)患者100名,随机分为中药治疗组、西药对照组,每组50例,分别给予中药补肾活血周期治疗联合西药和单纯西药人工周期治疗3月,比较治疗前后患者血清、子宫内膜中VEGF的变化及差异,同时观察2组患者术后再粘连情况。结果治疗后中药治疗组患者宫腔再粘连情况明显少于西药对照组(P<0.05)。2组药物治疗后血清中VEGF水平均下降,中药治疗组对血清VEGF下调作用优于西药对照组(t=2.165,P<0.05)。治疗后2组患者内膜VEGF表达存在差异,中药治疗组对子宫内膜VEGF表达的下调作用优于西药对照组(P<0.05)。结论补肾活血周期治疗能有效下调宫腔粘连患者血清及子宫内膜中VEGF的表达,从而对宫腔再粘连起到预防作用。
Objective Transcervical resection of adhensions was an effective treatment for intrauterine adhensions, but the main problems affecting the effectiveness was intrauterine adhensions recrudescence. Therefore, how to prevent the recru- descence was the purpose of this research. To investigate the effects of Bushen Huoxue therapy on the expression of VEGF in patients with intrauterine adhensions. Methods According to the random method and the single blind method, 100 ca- ses of intrauterine adhensions patients with TCRA were divided into two groups ： the traditional Chinese medicine group and the western medicine group. All patients were treated for 3 months. We observed the effects of the expression of VEGF in endometrium and blood,and observed the intrauterine adhesions after treatment. Results The palace cavity adhesion of Chinese medicine treatment was significantly less than western medicine group（ P 〈0.05 ）. The VEGF in blood of two groups were decreased. Chinese medicine treatment group was better than western medicine group（t = 2. 165 ,P 〈 0.05 ）. The VEGF in endometrium of two groups were different. Chinese medicine treatment group was better than western medi- cine group （P 〈 0.05）. Conclusion Bushen Huoxue therapy can downregulated expression of VEGF in endometrium and blood, then prevent the intrauterine adhesions.
出处
《中华全科医学》
2015年第6期961-963,共3页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2013ZB112)
作者简介
通信作者：常淑华，E-mail：changshuhuajx@126．com
