摘要
目的探讨缬沙坦对原发性高血压患者的降压作用和肾脏保护作用。方法选取2009年11月—2012年11月东莞市慢性病防治院收治的77例原发性高血压患者,随机分为观察组44例和对照组33例。观察组患者给予缬沙坦治疗,对照组患者给予依那普利治疗。比较两组患者治疗前后血压、肾功能及不良反应情况。结果两组患者治疗前1 d与治疗第4周收缩压、舒张压比较,差异无统计学意义(P>0.05);观察组患者治疗第8周收缩压与舒张压均低于对照组(P<0.05);两组患者治疗第4周和治疗第8周收缩压、舒张压均较治疗前1 d降低(P<0.05)。两组患者治疗前1 d血钾、肌酐、尿素氮、血β2-微球蛋白(β2-MG)、尿β2-MG及24 h尿蛋白定量比较,差异均无统计学意义(P>0.05);观察组患者治疗第8周血β2-MG、尿β2-MG及24 h尿蛋白定量均低于对照组(P<0.05)。观察组中5例患者(11.4%)出现不良反应,对照组中4例患者(12.1%)出现不良反应,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论缬沙坦不仅能有效降低原发性高血压患者的血压,还能有效保护患者肾功能。
Objective To evaluate the antihypertensive effect and renal protective effect of valsartan in patients with essential hypertension. Methods From November 2009 to November 2012,a total of 77 patients with essential hypertension were selected in the Chronic Diseases Control and Prevention Hospital of Dongguan, and they were randomly divided into observation group（ n = 44） and control group（ n = 33）. Patients of observation group were treated with valsartan, while patients of control group were treated with enalapril. Blood pressure, renal function and incidence of adverse reactions were compared between two groups before and after treatment. Results No statistically significant differences of the SBP,SDP was found between two groups 1 day before treatment and 4 weeks after treatment（ P〈0. 05）; SBP,SDP of observation group were lower than those of control group 8 weeks after treatment（ P〈0. 05）; SBP,SDP of both groups 4,8 weeks after treatment were lower than those 1 day before treatment（ P〈0. 05）. No statistically significant differences of serum potassium,creatinine,urea nitrogen,serum β2-MG, urine β2-MG and 24 h urine protein quantitative was found between two groups 1 day before treatment（ P〈0. 05）; serum β2-MG,urine β2-MG and 24 h urine protein quantitative of observation group were lower than those of control group 8 weeks after treatment（ P〈0. 05）. The incidence of adverse reactions of observation group was 11. 4%,that of control group was 12. 1%,the difference was not statistically significant（ P〈0. 05）. Conclusion Valsartan has certain antihypertensive effect and renal protective effect in patients with essential hypertension.
出处
《实用心脑肺血管病杂志》
2015年第2期69-71,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
高血压
缬沙坦
肾功能
治疗结果
Hypertension
Valsartan
Kidney function
Treatment outcome
