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静脉注射免疫球蛋白对T细胞的作用及其在自身免疫性疾病中的应用 被引量：6

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摘要 近年来,大剂量静脉注射用免疫球蛋白（intravenous immunoglobulin,ⅠⅥg）越来越广地应用在各种自身免疫性疾病的治疗中,并已成为了多种疾病的临床一线治疗药物,如特发性血小板减少性紫癜（idiopathic thrombocytopenia purpura,ITP）、川崎病（Kawasaki disease,KD）、周围性神经病、慢性炎性脱髓鞘性多神经病（chronic inflammatory demyelinating polyneuropathy,CIDP）以及吉兰—巴雷综合征（Guillain-Barre syndrome,GBS）和多发性硬化（multiple sclerosis,MS）等,以上疾病均属于自身免疫性疾病范畴。
作者 赵文婷 吴云 梁庆成
机构地区 哈尔滨医科大学附属第二医院神经内科
出处 《疑难病杂志》 CAS 2015年第4期427-430,共4页 Chinese Journal of Difficult and Complicated Cases
关键词 免疫球蛋白 T细胞 自身免疫性疾病
分类号 R593.2 [医药卫生—内科学]
作者简介 通信作者：梁庆成，E—mail：qingcheng_liang@126．com
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参考文献24

  • 1Ballow M. The IgG molecule as a biological immune response modifier: mechanisms of action of intravenous immune serum globulin in autoim- mune and inflammatory disorders [ J ]. J Allergy Clin lmmunol, 2011 , 127(2) :315-323.
  • 2Berger M, McCallus DE, Lin CS. IVIG in autoimmune neuromuscular Rapid and reversible responses to diseases suggest mechanisms of ac- tion involving competition with functionally important autoantibodies [ J ]. J Peripher Nerv Syst, 2013,18 ( 4 ) : 275-296.
  • 3Schneider-Hohendorf T, Schwab N, Ueyler N, et al. CDs+ T-cell immu- nity in chronic inflammatory demyelinating polyradiculoneuropathy[ J]. Neurology ,2012,78 ( 6 ) :402-408.
  • 4Mausberg AK, Dorok M, Stettner M, et al. Recovery of the T-cell rep- ertoire in CIDP by IV immunoglobulins [ J ]. Neurology, 2013,80 ( 3 ) : 296-303.
  • 5Thiruppathi M', Sheng JR, Li L, et al. Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gra- vis [ J]. J Autoimmun ,2014,42:64-73.
  • 6Wang YJ,Wang W, Gong FQ, et al. Evaluation of intravenous immuno- globulin resistance and coronary artery lesions in relation to Thl/Th2 cytokine profiles in patients with Kawasaki disease [ J 1. Arthritis Rheum,2013,65 (3) :805-814.
  • 7Kuo HC ,Wang CL,Liang CD,et al. Association of lower eosinophil-re- lated T helper 2 ( Th2 ) cytokines with coronary artery lesions in Ka- wasaki disease [ J ]. Pediatr Allergy Immuno1,2009,20 ( 3 ) :266-272.
  • 8Mouzaki A, Theodoropoulou M, Gianakopoulos I, et at. Expression pat- terns of Thl and Th2 cytokine genes in childhood idiopathic thrombocy- topenic purpura (ITP) at presentation and their modulation by intrave- nous immunoglobulin G (IVIg) treatment : their role in prognosis [ J ]. Blood, 2002,100 ( 5 ) : 1774 - 1779.
  • 9Reske D, Thomas AV, Petereit HF, et at. Impact of immunomodulatory treatment on leukocyte cytokine production in multiple sclerosis patients and healthy donors [ J ]. Neuroimmunomodulation ,2009,16 ( 6 ) :385-391.
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二级参考文献16

  • 1Dalakas MC.Intravenous immunoglobulin in the treatment of autoimmune neuromuscular disease:present status and practical therapeutic guidelines[J].Muscle Nerve,1999,22:1479-1497.
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  • 3Dalakas MC.Blockade of blocking antibodies in Guillain-Barre syndromes:''unblocking''the mystery of action of IVIG[J].Ann Neurol,2002,51:667-669.
  • 4Buchwald B,Ahangari R,Weishaupt A,et al.Intravenous immunoglobulins neutralize blocking antibodies in Guillain-Barre syndrome[J].Ann Neurol,2002,51:673-680.
  • 5Ghetic V,Ward ES.FcRn:the MHC Class I-related receptor that is more than an IgG transporter[J].Immunol Today,1997,18:592-598.
  • 6Campbell DE,Georgion GM,Kemp AS.Pooled human immunoglobulin inhibits IL-4 But Not IFN-γ OR TNF-α secretion following In vitro stimulation oF mononuclear cells with staphylococcal superantigen[J].Cytokine,1999,11:359-365.
  • 7Murata K,Dalakas MC.Expression of the costimulatory molecule BB-1, the ligands CTLA-4 and CD28,and their mRNA in chronic inflammatory demyelinating polyneuropathy[J].Brain,2000,123:1660-1666.
  • 8Basta M,IIIa I,Dalakas MC.Increased in vitro uptake of the complement C3b in the serum of patients with Guillain Barre syndrome, myasthenia gravis and dermatomyositis[J].J Neuroimmunol,1996,71:227-229.
  • 9Rieben AF,Gerritsen AF,Daha MR,et al.IgM enriched IVIG preparations are efficient scavengers of C4 as well as C3 and prevent complement-dependent cytotoxicity of human serum against pig cells[J].Novel Immunosupperessives and Xenotransplantation,1997,25:37
  • 10Samuelsson A,Towers TL,Ravetch JV.Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor[J].Science,2001,291:484-486.

共引文献7

同被引文献56

引证文献6

二级引证文献23

疑难病杂志
2015年 第4期

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