摘要
目的 联合应用PET/CT和功能MRI（fMRI）,研究静息状态下首发抑郁症患者的脑葡萄糖代谢、脑功能局部一致性（ReHo）的变化特点,以及两者间的关系.方法 分别对18例首发抑郁症患者[男6例,女12例,年龄（33.00±7.59）岁]与17名健康对照者[男6名,女11名,年龄（34.59±8.96）岁]行头颅PET/CT及fMRI.应用SPM及ReHo fMRI 1.0软件分析患者脑葡萄糖代谢及ReHo的异常改变.对PET及fMRI的结果进行相关分析.结果 与对照组相比,抑郁症患者双侧额上、中、下回,双侧颞上、中回,双侧豆状核、尾状核、左侧苍白球及双侧前扣带回代谢减低;双侧海马及左侧丘脑代谢增高;双侧额上、中回,双侧豆状核、左侧苍白球及左侧前扣带回ReHo减低;右侧海马及右侧丘脑的ReHo增高.双侧额上、中、下回,双侧颞上、中回,双侧豆状核,左侧尾状核,左侧苍白球、左侧前扣带回及双侧海马及双侧丘脑的SUV与ReHo值间均具有相关性（r=0.51 ～ 0.83,均P＜0.05）;右侧尾状核与右侧前扣带回的SUV与ReHo值间无相关性（r=0.41和0.37,均P＞0.05）.结论 抑郁症患者具有相对特征性的异常脑代谢和脑功能损伤模式,且其代谢与局部功能活性改变相一致.
Objective To investigate the changes of cerebral regional glucose metabolism and regional homogeneity （ReHo） and their relation in patients with major depression disorder （MDD） using 18F-FDG PET/CT and functional MRI （fMRI）.Methods A total of 18 MDD patients （6 males,12 females,age：（33.00±7.59） years） and 17 healthy controls （6 males,11 females,age：（34.59±8.96） years） underwent 18F-FDG PET/CT and fMRI.The changes of glucose metabolism on PET and ReHo on fMRI were analyzed individually by SPM and ReHo fMRI 1.0 software.Pearson correlation analysis was used.Results Compared with the glucose metabolism of control subjects,those of MDD patients decreased in the bilateral superior,middle and inferior frontal gyri,bilateral superior and middle temporal gyri,bilateral anterior cingulate cortices,bilateral putamina and caudate nuclei and the left pallidum.Meanwhile the glucose metabolism increased in the bilateral hippocampi and the left thalamus.The ReHo in MDD patients decreased in bilateral superior and middle frontal gyri,left pallidum,bilateral putamina,left anterior cingulate cortex,whereas increased ReHo was found in right hippocampus and right thalamus.The SUV of bilateral superior,middle and inferior frontal gyri,bilateral superior and middle temporal gyri,bilateral putamina,left caudate,left pallidum,left anterior cingulate cortex,bilateral hippocampi and bilateral thalami were correlated with ReHo （r =0.51-0.83,all P〈0.05）.However,no correlation was found between the SUV and ReHo in right caudate and anterior cingulate cortex （r=0.41,0.37; both P〉0.05）.Conclusion There may be relative characteristic models of abnormal cerebral metabolism and cerebral dysfunction impairment in MDD patients,and the changes of cerebral regional glucose metabolism may be correlated with the changes of ReHo.
出处
《中华核医学与分子影像杂志》
北大核心
2015年第1期27-31,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
2013年河南省国家临床重点专科建设项目
作者简介
通信作者：徐俊玲，Email：xjlllzq@163．com
