摘要
目的:探讨左乙拉西坦(LEV)添加疗法治疗青年难治性部分性癫痫的疗效,及对患者认知功能的影响。方法:62例难治性部分性癫痫青年患者随机分为A组(n=32)和B组(n=30)。B组给予苯巴比妥片+卡马西平片治疗,A组在B组基础上加用左乙拉西坦片。均持续给药6个月后,比较两组临床疗效、患者认知功能及生活质量差异,以及药品不良反应发生情况。结果:治疗后,A组治疗后12周与24周的总有效率均明显高于B组(P<0.05);A组患者Mo CA评估及SF-36评估评分也均优于B组(P<0.05)。两组药品不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对患难治性部分性癫痫的青年患者给予常规药物联合LEV疗法,疗效确切,对其认知功能的提升具有积极意义,值得临床推广。
Objective： To investigate the efficacy of levetiracetam（ LEV） in the treatment of refractory partial epilepsy in young people and its effect on cognitive function. Methods： Totally 62 young patients with refractory partial epilepsy were randomly divided into the levetiracetam group（ group A,n = 32） and routine treatment group（ group B,n = 30）. Group B was treated with phenobarbital tablets plus carbamazepine tablets,and group A was given LEV tablets additionally. After 6-month treatment,the clinical curative effect,cognitive function,quality of life and adverse drug reactions were compared between the two groups. Results： After the treatment,the total effective rate at the 12 th and 24 th week in the group A was significantly higher than that in the group B（ P〈0. 05）. The Mo CA scores and SF-36 scores in the group A were much better than those in the group B（ P〈0. 05）. There was no significant difference in adverse drug reactions between the two groups（ P〉0. 05）. Conclusion： Routine medicine combined with LEV in the treatment of refractory partial epilepsy in young patients shows definite curative effect and positive significance for the promotion of cognitive function,which is worthy of clinical promotion.
出处
《中国药师》
CAS
2015年第4期613-615,共3页
China Pharmacist
关键词
左乙拉西坦
添加疗法
难治性部分性癫痫
认知功能
Levetiracetam
Additive therapy
Refractory partial epilepsy
Cognitive function
作者简介
通讯作者：吕志芳Tel：13588568366 E-mail：lvzhifang133@126．com
