摘要
Objective:To investigate the correlation of serum apoptotic molecule and cytokine levels with cognitive function in epileptic patients.Methods: 78 adult epileptic patients admitted to our hospital between December 2016 and December 2018 were selected as the epilepsy group, and 50 normal people who underwent physical examination in our hospital during the same period were selected as the normal control group. The differences in serum levels of apoptotic molecules [bcl-1, bax, survivin, caspase-3, caspase-4 and caspase-10], inflammatory factors [interleukin-1β (IL-1β), interleukin-2 (IL-2), tumor necrosis factor (TN-α) and high mobility group protein B1 (HMGB1)], oxidative stress indexes [advanced oxidation protein product (AOPP), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px)] and adipokines [adiponectin (APN) and leptin] as well as Mini-Mental State Examination (MMSE) scores were compared between the two groups, and Pearson test was used to evaluate the correlation of serum apoptotic molecule and cytokine levels with cognitive function in patients with epilepsy.Results: Serum bcl-1 and survivin levels in the epilepsy group were lower than those in the normal control group, while bax, caspase-3, caspase-4 and caspase-10 levels were higher than those in the normal control group;serum IL-1β, IL-2, TNF-α and HMGB1 levels were all higher than those in the normal control group;serum AOPP and MDA levels were higher than those in the normal control group, while GSH-Px level was lower than that in the normal control group;serum APN level was lower than that in the normal control group, while Leptin level was higher than that in the normal control group;MMSE score was significantly lower than that in the normal control group (P<0.05). Pearson test showed that the serum levels of apoptotic molecules, inflammatory factors, oxidative stress indexes and adipokines in epileptic patients were directly correlated with MMSE score (P<0.05).Conclusion:The cognitive function of epileptic patients is affected by apoptosis, inflammatory stress response, adipokine expression and other factors. Active regulation of the above internal environment factors may be one of the means to improve the cognitive status of epileptic patients.
作者简介
Corresponding author:Mei-Mei Yang,Heart and Lung Center,the Fifth Hospital of Sichuan Province,Chengdu,Sichuan Province,610031,China.
