摘要
目的探讨表皮生长因子受体（epidermal growth factor receptor,EGFR）和肝细胞生长因子受体（mesenchymal-epithelial transition factor,c-Met）在声门型喉鳞癌中的表达及与术后复发之间的关系。方法共纳入66例声门型喉磷癌患者,复发组和未复发组各33例。免疫组化法检测c-Met及EGFR在原发灶组织的表达情况,用H评分法对免疫组化结果进行评估。定义H评分值高于中位值为高表达,相反为低表达。结果在总群体中,c-Met和EGFR的H评分中位值分别为150（0~270）和225（0~270）。单变量Logistic回归分析表明,c-Met或EGFR高表达患者的复发风险显著高于低表达患者（OR=7.111,P〈0.001;OR=5.290,P=0.002）。逐步回归分析表明c-Met或EGFR的高表达均可作为声门型喉癌术后复发的独立危险因素（OR=5.909,P=0.002;OR=4.231,P=0.013）。ROC曲线分析显示联合检测c-Met和EGFR的表达情况对评估术后复发风险具有良好的预测效能（AUC=0.795,95%CI：0.685~0.905）。结论 c-Met和EGFR的表达均与声门型喉磷癌术后复发密切相关,可作为术后复发的有效预测指标。
Object ve To explore the relationship between mesenchymal-epithelial transition factor （c-Met） and epidermal growth factor receptor （EGFR） expression and postoperative recurrence in glottic laryngeal squamous cell carcinoma （LSCC）. Methods Immunohistochemistry accompanied with H scores was utilized to evaluate the expression of c-Met and EGFR in primary focus tissues of 66 patients with glottic LSCC, who were equally divided into a recurrence group and a non-recurrence group. If H scores were greater than the median values, the c-met and EGFR expression was defined as high expression, and conversely, low expression was defined. Results The median values of H-scores of c-Met and EGFR were 150 （0 -270） and 225 （0 -270）, respectively. The univariate logistic regression analysis showed that the recurrence risk was significantly increased in the patients with high expression of c-Met or EGFR compared with the patients with low expression （ OR = 7. 111, P 〈 0. 001 ; OR = 5. 290, P = 0. 002）. Stepwise regression analysis suggested that high expression of c-Met or EGFR was independent prognostic factor for recurrence after LSCC operation （ OR = 5. 909, P = 0. 002 ; OR = 4. 231, P = 0. 013 ）. ROC curve analysis showed that combined detection of c-Met and EGFR expression had moderate predictive value for postoperative recurrence （AUC = 0. 795, 95% CI： 0. 685 - 0. 905 ）. Conclusion The expression levels of c-Met and EGFR are closely correlated with postoperative recurrence of glottic LSCC, and can be used as indicators for recurrence of glottic LSCC.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2015年第6期553-557,共5页
Journal of Third Military Medical University
关键词
声门型喉鳞癌
肝细胞生长因子受体
表皮生长因子受体
术后复发
glottic laryngeal squamous cell carcinoma
mesenchymal-epithelial transition factor
epidermal growth factor receptor
postoperative recurrence
作者简介
[通信作者]王阁，电话：（023）6875717，E—mail：wangge70@hotmail．com
