摘要
肝脏是人体储存铁离子的主要器官,因此铁离子代谢失常与慢性肝炎密切相关。目前,慢性丙型肝炎(CHC)中铁离子过载的机制并没有完全阐明。铁调素调控非常复杂,依赖于许多变量,包括不同阶段的肝脏炎症情况、转铁蛋白参与的铁离子循环以及胞内铁离子储存等,这些因素都与引起HCV相关肝脏疾病患者中铁离子浓度的变化有关。讨论了系统铁离子稳态的调控、CHC与铁离子失调的关系及诱发CHC铁离子过载的机制。认为深入认识铁离子稳态和相关信号通路之间的关系将促进HCV相关疾病的控制与治疗。
Since the liver is the major iron storage organ in human body, iron metabolism disorder is closely related to chronic hepatitis. So far, the mechanisms underlying iron overload in chronic hepatitis C （CHC） have not been fully elucidated. Highly complex regulation of hepcidin relies on a number of variables, including hepatic inflammatory conditions of different stages, transferrin - bound iron circulation, and intracellular iron storage. All these factors are associated with variations in hepatic iron concentrations among patients with hepatitis C vi- rus （HCV） -related chronic liver disease. This paper discusses the regulation of systemic iron homeostasis, the relationship between CHC and iron metabolism disorder, and the mechanism of inducing iron overload. In - depth understanding about iron homeostasis and the rela- tionship between relevant signaling pathways will contribute to the control and therapy of HCV - related diseases.
出处
《临床肝胆病杂志》
CAS
2015年第2期291-294,共4页
Journal of Clinical Hepatology
关键词
肝炎
丙型
慢性
受体
转铁蛋白
铁蛋白质类
铁代谢障碍
综述
hepatiitis C, chronic
iron overload
receptors, transferrin
iron metabolism disorders
review
作者简介
秦源（1985－），男，实验员，主要从事HCV感染机制的研究。
通信作者：贾战生，电子信箱：jiazsh@fmmu．edu．cn。
