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铁代谢与肿瘤生成 被引量：2

Iron metabolism and oncogenesis
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摘要 铁代谢与肿瘤发生、发展、转移及血管生成密切相关。肿瘤患者体内的铁蛋白及其受体、转铁蛋及其受体普遍呈高表达，而去铁除了可抑制肿瘤的生长外，还可减轻基质金属蛋白酶相关的肿瘤细胞的转移。 Iron metabolism is involved in cancer initiation, progression, metastasis, and angiogenesis. Ferritin,ferritin receptor, transferrin, and transferrin receptor are often overexpressed in cancers. Not only iron deprivation can inhibit the growth of cancers, but also may suppress matrix metalloproteinases-related metastasis.
作者 程哲(综述) 刘玉峰(审校)
机构地区 郑州大学第一附属医院呼吸科河南省高等学校临床医学重点学科开放实验室
出处 《国际肿瘤学杂志》 CAS 2010年第8期570-572,共3页 Journal of International Oncology
关键词 铁代谢障碍 转铁蛋白 受体 转铁蛋白 肿瘤 Iron metabolism disorders Transferrin Receptors, transferrin Neoplasms
分类号 R556 [医药卫生—血液循环系统疾病]
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参考文献19

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二级参考文献4

共引文献14

同被引文献47

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  • 3张景,刘元明,张薇,王贝晗,郝钦芳,刘爱兵.血清铁蛋白测定对几种恶性肿瘤的诊断价值[J].武警医学,2007,18(1):74-75. 被引量：15
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  • 5Habashy HO,Powe DG,Staka CM,et al.Transferrin receptor (CD7I) is a maker of poor prognosis in breast cancer and can predict response to tamoxifen.[J].Breast Cancer Bes Treat, 2010,119(2) : 283-293.
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  • 10Kaomongkolgit R,Cheepsunthorn P,Pavasant P,et al.lron increases MMP--9 expression through activation of AP-1 via ERK/Akt pathway in hu- man head and neck squamous carcinoma cells.Oral Oncol,2008,44(6):587-594.

引证文献2

国际肿瘤学杂志
2010年 第8期

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