摘要
中药成分的生物学活性评价是探索中药药效物质基础的主要手段。分别从整体动物、细胞、分子3个层面,系统论述了10年来该领域的技术进展,以及依托新技术筛选出的新中药活性组分及单体化合物。同时分析了不同技术的长处及不足,以期能为中药新药研发提供资料及思路。
Biological activity evaluation of Chinese materia medica（CMM） composition is one of the main means to explore the active components of CMM. This paper, from the three aspects of whole animal, cellular, and molecular, discusses systematically the technical progress in this area over the past 10 years and the screening of new active ingredients from CMM and monomer compounds based on new technology. At the same time, the different technical strengths and weaknesses have been analyzed in the hope of providing the information and ideas for the research on the new drugs of CMM.
出处
《中草药》
CAS
CSCD
北大核心
2015年第4期588-594,共7页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81173164)
关键词
中药活性成分
生物学活性评价
膜亲和色谱
生物大分子亲和色谱
高效液相色谱-柱后生物活性联机检测
bioactive components in Chinese materia medica
biological activity evaluation
membrane affinity chromatography
biomacromoleculer affinity chromatography
high performance liquid chromatography-biological activity after column on-line detection
作者简介
作者简介：李建锋（1988-），男，硕士研究生，研究方向为中医药防治心脑血管疾病的机制研究。
通信作者赵启韬，女，博士，副教授，硕士生导师。Tel：（0531）89628501E-mail：qitaozhao@163.com
