摘要
目的:探讨电针丰隆穴对高脂血症大鼠肝脏组织炎症细胞因子的调控作用。方法:将30只健康SD大鼠随机分为正常组、模型组、电针组各10只。电针组给予丰隆穴电针治疗。4周后,检测各组大鼠血脂水平,即总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量,ELISA检测各组大鼠肝脏组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、干扰素-γ(IFN-γ)蛋白水平变化。结果:治疗后,血脂水平比较,与正常组比较,模型组大鼠TC、TG及LDL-C均显著升高(P<0.01,0.05),HDL-C显著降低(P<0.05),电针组的TC、LDL-C均显著升高(P<0.01)。与模型组比较,电针组大鼠TC、TG及LDL-C均显著降低(P<0.01,0.05),HDL-C显著升高(P<0.05)。肝脏组织炎症因子蛋白水平比较,与正常组比较,模型组炎症因子TNF-α、IL-1β、IFN-γ均有显著性升高(P<0.05,0.01),电针组炎症因子差异均无统计学意义。与模型组比较,电针组炎症因子均明显降低(P<0.05,0.01)。结论:电针丰隆穴能够明显下调高脂血症大鼠血脂中TC、LDL-C水平,并能降低肝脏组织中炎症因子TNF-α、IL-1β、IFN-γ的蛋白水平变化,对高脂血症具有一定的治疗作用。
Objective：To study the modutory effect of electroacupuncture at the ＂ Fenglong＂ on inflammatory factors in the livers of rat hyperlipidemia model.Methods：Thirty health male SD rats were selected and randomly divided into 3groups：normal control group（A）,model control group（B）,and electroacupuncture group（C）.After four weeks,blood lipids of rats were determined.The protein levels of TNF-α,IL-1βand IFN-γin the livers of rat hyperlipidemia model were detected by ELISA.Results：As compared with group A,the contents of TC,TG and LDL-C were significantly increased（P〈0.01,or P〈0.05）and the content of HDL-C was significantly decreased（P〈0.05）in group B,and the contents of TC and LDL-C were significantly increased in group C（P〈0.01）.As compared with group B,the contents of TC,TG and LDL-C were significantly reduced（P〈0.01）,and those of HDL-C significantly increased in group C（P〈0.05）.As compared with group A,TNF-α,IL-1βand IFN-γlevels were increased significantly in group B（P〈0.05,and P〈0.01）.As compared with group B,TNF-α,IL-1βand IFN-γlevels in group C were decreased significantly（P〈0.05,and P〈0.01）.Conclusion：Electroacupuncture at ＂Fenglong＂ can notably decrease the levels of TC and LDL-C,and the protein levels of TNF-α,IL-1βand IFN-γin the liver tissues,suggesting its certain therapeutical effectiveness on hyperlipemia.
出处
《中国康复》
2015年第1期7-9,共3页
Chinese Journal of Rehabilitation
基金
国家自然科学基金项目(30873309)
作者简介
乐薇（1981-），女，主治医师，主要从事针灸穴位究。
通讯作者：张红星，zhxzj99@yahoo．com．cn
