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EML4-ALK融合基因-非小细胞肺癌治疗的新靶点 被引量:13

EML4-ALK fusion gene:a novel target for non-small cell lung cancer
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摘要 EML4-ALK融合基因是目前非小细胞肺癌,特别是肺腺癌的一个新的驱动基因。目前,针对该基因的检测方法、该基因阳性患者的临床病例特征及依据检测结果进行靶向性治疗等领域取得了不少新成果。本文就该基因在上述方面取得的进展作一系统综述。 EML4-ALK fusion gene is a novel oncogene of non-small cell lung cancer, especially of adenocarcinoma of lung. Currently, significant progress has been made in these aspects: detection methods, the clinical pathological characters of EML4-ALK fusion gene patients and target therapy according the genotyping. We here summarize recent progress in the development of EML4-ALK fusion gene in these areas.
出处 《分子诊断与治疗杂志》 2015年第1期50-54,共5页 Journal of Molecular Diagnostics and Therapy
基金 国家自然科学基金(81172081) 中国博士后基金(2012M521189) 浙江省博士后择优专项基金(Bsh1202064) 浙江省自然科学基金(LY13H160024)
关键词 非小细胞肺癌 EML4-ALK 靶向治疗 Non-small cell lung cancer EML4-ALK Target therapy
作者简介 通讯作者:谢发君,E-mail:fjxie@foxmail.com
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