摘要
目的:考察注射用盐酸头孢甲肟与注射用阿昔洛韦在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在室温下观察盐酸头孢甲肟与注射用阿昔洛韦配伍后的外观及p H值变化,并采用高效液相色谱法测定两药的含量变化。结果:两药配伍后在6 h内外观及p H值均无明显变化,阿昔洛韦含量均大于97%,但头孢甲肟含量下降至79.41%。结论:注射用盐酸头孢甲肟不能与注射用阿昔洛韦在0.9%氯化钠注射液和5%葡萄糖中配伍使用。
OBJECTIVE： To investigate the compatible stability of Cefmenoxime for injection with Acyclovir for injection in 0.9% Sodium chloride injection and 5% Glucose injection. METHODS： At room temperature, the appearance and pH of the mix- tures were observed, and HPLC method was adopted to determine the contents of cefmenoxime and acyclovir after Cefmenoxime for injection combined with Acyclovir for injection. RESULTS： No significant change was noted for the mixture in appearance and pH value within 6h. The content of acyclovir was higher than 97 %, and that of cefmenoxime was higher than 79.41%. CONCLU- SIONS： The mixture is stable at room temperature after Cefrnenoxime for injection is mixed with Acyclovir for injection in Sodium chloride injection and 5% Glucose injection.
出处
《中国药房》
CAS
北大核心
2015年第2期198-200,共3页
China Pharmacy
基金
河北省医学科学研究重点课题(No.20120276)
作者简介
主管药师，硕士。研究方向：药物的降解动力学及配伍稳定性。电话：0311-85917352。E-mail：wjx1561@126．com
通信作者：主任药师，硕士生导师。研究方向：药物稳定性。电话：0311-85917352。E-mail：yjzh1957@163．com
