摘要
以3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-氨基-头孢烷酸盐酸盐(7-ATCA.HC l)为原料,在C7-NH2位置上用活性酯法与侧链化合物2-(2-氨基-4-噻唑基-2-(Z)-甲氧亚胺基乙酸缩合得到头孢甲肟,然后在水溶液中与盐酸成盐而制得盐酸头孢甲肟。以7-ATCA.HC l为基准,总合成收率在66%以上,产物为高纯度结晶性粉末。
This paper describes the preparation process of cefmenoxime hydrochloride [(CMX)_2·HCl]. 3-[(1-methyl-1H-tetrazol-5-yl-thio)-methyl]-7-amino-cephalosporanic acid hydrochloride (7-ATCA·HCl) as the starting material, was condensed with the side chain compound 2-(2-amino-4-thiazol)-2(z)methyloxy-imino acetic acid on C_7- position via the active ester method and then the condensed product cefmenoxime (CMX) might be converted to its hydrochloride [(CMX)_2·HCl]. The total yield of the process was more than 66% (based on 7-ATCA·HCl). The product was obtained as a crystalline powder in high purity.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2005年第7期396-398,共3页
Chinese Journal of Antibiotics
关键词
头孢甲肟
盐酸头孢甲肟
7-ATCA·HCl
氨噻肟乙酸
合成
Cefmenoxime
Cefmenoxime hydrochloride
7-ATCA·HCl
2-(2-amino-4-thiazol)-2(z)methyloxy-imino acetic acid
Synthesis process
