摘要
目的 观察细胞周期素G2 （CCNG2）和M2型丙酮酸激酶（PKM2）在胃癌组织中的表达,探讨两者与胃癌临床病理特征的关系及预后价值.方法 应用免疫组织化学法检测51例胃癌患者手术切除的癌组织和癌旁组织中CCNG2和PKM2表达水平.结果 CCNG2在胃癌组织的表达率明显低于癌旁组织（62.75％比94.12％,P＜0.01）,CCNG2表达水平与胃癌组织学分化程度、TNM分期、淋巴结转移明显相关（P＜0.05）;PKM2在胃癌组织的表达率明显高于癌旁组织（72.55％比27.45％,P＜0.01）,PKM2表达水平与胃癌TNM分期、淋巴结转移明显相关（P＜0.05）.结论 CCNG2和PKM2在胃癌的发生、发展中发挥重要作用.
Objective To study the expression of Cyclin G2 （CCNG2） and M2-pyruvate kinase （PKM2） in gastric carcinoma and their clinical significances.Methods The expression levels of CCNG2 and PKM2 in 51 cases of gastric carcinoma tissues and adjacent gastric tissues （5 cm distance away from the margin of gastric carcinoma） were detected by using immunohistochemical method.Results The expression rate of CCNG2 in gastric carcinoma tissues was lower than that of non-cancerous adjacent gastric tissues （62.75% vs.94.12%,P 〈0.01）.The expression of CCNG2 was related to histology grade,TNM stage and lymph node metastasis （P 〈 0.05）.The expression rate of PKM2 in gastric carcinoma tissues was higher than that of non-cancerous adjacent gastric tissues （72.55% vs.27.45%,P 〈 0.01）,and the expression of PKM2 was related with TNM stage and lymph node metastasis （P 〈 0.05）.Conclusion CCNG2 and PKM2 are closely correlated to carcinogenesis,development and metastasis of gastric carcinoma,indicating they may be used as biological indicators to evaluate the degree of malignancy of gastric carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第11期2562-2563,共2页
Chinese Journal of Experimental Surgery
作者简介
通信作者：许庆文，Email：xuqwen@tom．com
