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客观评价泪液渗透压检查在干眼诊断与疗效评估中的临床意义 被引量:8

Rethinking clinical significance of tear osmolarity measurement for dry eye diagnosis and therapeutic efficacy evaluation
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摘要 已有大量研究支持泪液渗透压升高是干眼病理生理过程的核心环节和重要的辅助诊断依据,有学者提出泪液渗透压升高可以作为干眼诊断的“金标准”.然而,近年一些研究给出了不同的甚至相反的结论,认为泪液渗透压在干眼的诊断和评价中作用有限.泪液渗透压检测的临床意义成为干眼研究的一个争论焦点.在此,笔者对泪液渗透压的相关临床研究进行了回顾,对争议背后可能的深层次原因进行了分析,除为客观评价该指标的临床意义提供参考外,更希望为开展进一步相关机制研究提供思路. Increased tear osmolarity is one of the core mechanisms of dry eye and has been considered as an important diagnostic criterion,if not" gold standard",of dry eye.However,recent studies showed the limitations of tear osmolarity measurement not only in the diagnosis,but also in the therapeutic efficacy evaluation of dry eye.The clinical significance of tear osmolarity measurement has become a hot topic of argument.Herein,we review the publications on this topic and try to find the underlying causes of such argument.
出处 《中华眼科杂志》 CAS CSCD 北大核心 2014年第9期650-654,共5页 Chinese Journal of Ophthalmology
关键词 干眼综合征 眼泪 渗透压 Dry eye syndromes Tears Osmotic pressure
作者简介 通信作者:刘祖国,Email:zuguoliu@xmu.edu.cn
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