摘要
人参及其有效成分因具有卓越的增强免疫、调节内分泌及抗氧化应激等作用而著称,然而各成分功效之间的差别并不明确。该文以实验大鼠为对象,研究人参主要有效成分一人参总皂苷、三醇皂苷、二醇皂苷以及人参多糖对机体的影响。结果显示人参二醇皂苷和多糖在提升动物免疫器官质量、血浆白细胞介素2(IL-2)、白细胞介素6(IL-6)、血浆δ干扰素(IFN-γ)、肿瘤坏死因子α(TNF-α)方面的作用优于其他组。总皂苷和三醇皂苷可有效增加脾脏天然杀伤细胞(NKC)的含量。二醇皂苷和多糖可以显著增加大鼠血浆促肾上腺皮质激素(ACTH)、皮质酮(CORT)和促甲状腺激素(TSH)含量。人参总皂苷在增加大鼠脑组织一氧化氮(NO)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)和丙二醛(MDA)方面优于其他各组。研究表明,人参各成分在增强免疫、调节内分泌及抗氧化应激方面有不同程度的功效,人参二醇皂苷和人参多糖在增强免疫方面体现优势,人参总皂苷在抗氧化应激方面体现优势。
Ginseng and its effective components are famous for their influence to enhance human immunity, regulate endocrine and antioxidant action. However, the different effects of different components are not clear. In this study, Wistar rats were used to study the effects of main components of ginseng, including total ginsenoside, panaxadiol saponins, panaxtrol saponin and ginseng polysaccharide. The results showed：that the effects of panaxadiol saponins and ginseng polysaccharide on improving animal immune organ weight, plasma interleukin 2 （IL-2）, interleukin 6 （IL-6）, plasma gamma-interferon （IFN-T） , tumor necrosis factor alpha （TNF-α） were better than that of the other groups. Total ginsenoside and panaxtrol saponin can effectively increase the concentration of spleen NK cells （NKC） while panaxadiol saponins and ginseng polysaccharide can significantly increase the concentrations of rat plasma adrenocorticotrophic hormone （ACTH） , corticosterone （CORT） and thyroid stimulating hormone （TSH）. As for the effect of increasing organization nitric oxide （NO） and superoxide dismutase （SOD）, glutathione （GSH） and malondialdehyde （MDA）, total ginsenoside is better than that of other groups. In brief, different components in ginseng possess different effects on enhancing immunity, regulating endocrine and resisting oxidation. Panaxadiol saponins and ginseng polysaccharide are better in enhancing immune, and total ginsenoside shows advantages in resisting oxidation and stress.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第17期3363-3366,共4页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30901997)
国家重点基础研究发展计划(973)项目(2012CB910102)
上海交通大学SMC-晨星学者计划(B类)
关键词
人参皂苷
人参多糖
内分泌系统
免疫系统
抗氧化应激
ginsenoside
ginseng polysaccharide
endocrine system
immune system
antioxidation and antistress
作者简介
[通信作者]王晓艳，副研究员，Tel：（021）34204052，E-mail：cathywxy@sjtu．edu．cn
