摘要
流行病学和病理研究证据表明,胚胎发育期间母体高脂血症增加了后代成年后动脉粥样硬化的风险。在子宫、胎盘和胎儿暴露于来自母亲的高胆固醇、脂质入侵、氧化应激、炎症和免疫反应等信号,胎儿对这些反应可能导致表观遗传的改变,使其在成年后动脉粥样硬化易感性增加。
An increasing amount of epidemiological and pathological evidence has been provided that indicates that maternal hyperlipidemia during embryonic development is correlated with an increased risk for atheroselerosis in the off- spring during adulthood. In utero, the placenta and fetus are exposed to high cholesterol, lipid invasion, oxidative stress, inflammation and immune reaction signals from the mother and will likely respond specifically. In the fetus, these responses may lead to permanent epigenetie changes and these changes may lead to increased atherosclerosis susceptibility in adult- hood.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2014年第6期633-636,共4页
Chinese Journal of Arteriosclerosis
作者简介
高胜利，硕士，讲师，研究方向为动脉粥样硬化，E—mml为ga01583@sina．com。
高淑红，硕士，讲师，研究方向为药物流行病学。
赵成瑞，硕士，讲师，研究方向为动脉粥样硬化。
