摘要
目的观察不同2型糖尿病证型患者血清微量元素锌、钙、铁、铜、镁含量变化。方法分别采集30例健康对照组和500例不同证型2型糖尿病患者肘静脉血各5 ml,离心后取其全部血清,用血清多元素分析仪,用火焰法检测五种微量元素(锌、钙、铁、铜、镁)含量。结果 2型糖尿病患者可分为痰湿中阻型、阴虚内热型、气阴两虚型、气滞血瘀型、阴阳两虚型五种中医证型,分别将锌、钙、铁、铜、镁的含量与健康对照组比较,结果显示:各证型糖尿病患者较健康对照组微量元素,铁、铜、钙含量升高,锌、镁含量降低,差异有统计学意义(P<0.05)。其中阴虚内热及气阴两虚型患者与其他各型比较,虽差异无统计学意义(P>0.05),但上述元素差异变化有逐渐增加的趋势。结论不同证型的糖尿病患者,应使体内各种元素保持正常含量和比值,患者体内元素含量过高或者过低,应采取平衡处理措施。了解不同证型糖尿病患者血清元素含量变化,对糖尿病的临床治疗有一定价值。
Objective To observe the change of serum microelements, such as zinc, calcium, iron, copper, magnesium, in patients of type 2 diabetes with different symptoms. Methods Blood samples of 5 ml of elbow venous blood were taken from health group of 30 cases and 500 patients of type 2 diabetes with different symptoms. After centrifugation, all the serums were analyzed by serum element analyzer. And five microelements （zinc, calcium, iron, copper, magnesium） levels were detected by flame method. Results There were five syndrome patterns of type 2 diabetes in traditional Chinese medicine, and the patterns were syndrome with phlegm-damp and centre-resistance, syndrome with internal heat and Yin deficiency, syndrome with Qi-Yin deficiency, syndrome with Qi depression and blood stasis, and syndrome with Yin- Yang deficiency. The comparisons of microelements level between the patients and the health group showed that the level of calcium, iron, and copper were increased in patients with diabetes, and the levels of zinc and magnesium were decreased. The differences were statistically significant （P〈O.05）. Although there were no significant differences between the microelements levels in patients with internal heat and Yin deficiency syndrome and Qi-Yin deficiency syndrome and those in the other three groups, the change of differences of those groups had a increasing trend （P〉0.05）. Conclusion The level of microelements should be balanced in content and proportion for patients of type 2 diabetes with different symptoms. Balance measures should be applied when the level is too low or high. Knowing different levels of microelement in different symptoms is valuable for clinical treatment of diabetes.
出处
《中国现代药物应用》
2014年第19期9-11,共3页
Chinese Journal of Modern Drug Application
基金
桂林市科学研究与技术开发项目(项目编号:2011011 9-1-13)
关键词
2型糖尿病
同病异证
微量元素
Type 2 diabetes
Same disease different symptoms
Microelement
