摘要
目的探讨氨基末端B型脑钠肽前体(N-terminal pro-brain natiuretic peptide,NT-proBNP)水平在心力衰竭诊断及分级诊断中的意义。方法心力衰竭患者120例,按NYHA心功能分级分为Ⅰ、Ⅱ、Ⅲ、Ⅳ级组各30例,同期60例体检健康者为对照组,检测各组血清NT-proBNP水平,并进行比较。结果 NYHA心功能分级Ⅰ、Ⅱ、Ⅲ、Ⅳ级组NT-proBNP水平分别为(398.3±54.3)、(1 259.0±380.6)、(3 401.0±655.5)、(15 802.0±6 577.6)ng/L,均高于对照组((116.6±50.7)ng/L)(P<0.01),组间比较差异均有统计学意义(P<0.05)。结论血清NT-proBNP水平可有效反映心功能状况,可用于心力衰竭的诊断和分级诊断。
Objective To explore the significance of N-terminal pro-brain natriuretic peptide（NT-proBNP）in the diagnosis and grade diagnosis of heart failure.Methods A total of 120 patients with heart failure（observation group）were divided into NYHA cardiac function gradeⅠ,Ⅱ,ⅢandⅣgroups,with 30 patients in each group,and another 60 health volunteers were as controls（control group）.The serum NT-proBNP levels were detected and compared among groups.Results The NT-proBNP levels were（398.3±54.3）,（1 259.0±380.6）,（3 401.0±655.5）and（15 802.0±6 577.6）ng/L respectively in NYHA cardiac function gradeⅠ,Ⅱ,Ⅲ andⅣ groups,showing significant differences among four groups（P〈0.05）,higher than that in control group（（116.6±50.7）ng/L）（P〈0.01）.Conclusion The serum level of NT-proBNP can effectively reflect the cardiac function,and can be used in the diagnosis and grading diagnosis of heart failure.
出处
《中华实用诊断与治疗杂志》
2014年第8期815-816,共2页
Journal of Chinese Practical Diagnosis and Therapy
关键词
心力衰竭
氨基末端B型脑钠肽前体
B型脑钠肽
Heart failure
N-terminal pro-brain natiuretic peptide
brain natriuretic peptide
