摘要
目的探讨锯叶棕果实提取物治疗慢性前列腺炎/慢性骨盆疼痛综合征(chronic prostatitis/chronic pelvic pain syndrome,CP/CPPS)的疗效。方法选择我科门诊2011年3月至2013年5月收治的Ⅲ型前列腺炎患者118例,包括ⅢA型46例,ⅢB型72例。口服锯叶棕果实提取物,160 mg/次,2次/d,8周一疗程。以美国国立卫生研究院慢性前列腺炎症状评分(NIH-CPSI)、前列腺液常规白细胞计数和国际勃起功能评分问卷(international conventional erectile function score questionnaire,IIEF-5)评分为疗效评价指标,进行治疗前后比较。结果 115例患者完成治疗和随访,包括ⅢA型CP45例,ⅢB型CP 70例。患者口服锯叶棕果实提取物后,NIH-CPSI评分及前列腺液白细胞计数均显著降低(P<0.05)。治愈23例(20.0%),显效32例(27.8%),有效42例(36.5%),无效18例(15.7%),总有效率84.3%。IIEF-5评分有所升高(P>0.05)。未发生明显不良反应。结论锯叶棕果实提取物单独用于治疗前列腺炎(尤CP/CPPS),对减轻患者疼痛、改善排尿症状及提高生活质量有较好疗效,且没有明显不良反应。
Objective To explore the effectiveness of saw palmetto extract in treating chronic prostatitis /chronic pelvic pain syndrome（CP /CPPS）.Methods Chronic prostatitis type Ⅲ patients were enrolled in this study,118 cases with 46 cases of chronic prostatitis type ⅢA and 72 cases of type ⅢB.All of the patients accepted oral administration of saw palmetto extract of 160 mg,2 times per day,for 8 weeks.NIH-chronic prostatitis symptom index（NIH-CPSI）,leukocyte counting in prostatic fluid and international conventional erectile function score questionnaire（IIEF-5） score were used to evaluate the effectiveness.Results A total of 115 cases accomplished treatment,including 45 cases of type ⅢA,and 70 cases of type ⅢB.After patients were treated with saw palmetto extract,the NIH-CPSI score and leukocytes in prostatic fluid decreased significantly（P 0.05）.The total effective rate was 83.3%,with 23 cases（20.0%） cured,32 cases（27.8%）having notable effects,42 cases（36.5%） having effects,and 18 cases（15.7%） having no effect.IIEF-5 score increased,without significant difference（P 0.05）.No apparent side effect was observed in all patients.Conclusion Saw palmetto extract alone is safe and effective in treatment of prostatitis,especially CP /CPPS,and significantly reduces pain,relieves urinary symptoms and improves quality of life,without significant side effect.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2014年第14期1504-1506,共3页
Journal of Third Military Medical University
基金
重庆市自然科学基金(CSTC2013jcyjA10137)
全军医学科研"十一五"计划面上项目(06MB246)~~
作者简介
[通信作者]卢根生，E-mail：lugensheng@sina．com
