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番茄红素对小鼠免疫功能的促进作用 被引量：21

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摘要 目的研究不同剂量番茄红素对小鼠免疫功能的影响。方法昆明种小鼠随机分为低、中、高3个剂量组和阴性对照组,剂量组动物分别灌胃给予0.37、3.67和11 mg/kg·BW的番茄红素,阴性对照组给予食用植物油,连续灌胃30 d后,对小鼠进行细胞免疫指标、体液免疫指标、巨噬细胞吞噬功能及NK细胞活性测定。结果中和高剂量组小鼠足跖肿胀度值明显高于阴性对照组(P<0.01),高剂量组小鼠脾脏抗体生成数明显高于阴性对照组(P<0.01),中和高剂量组小鼠腹腔巨噬细胞吞噬率和吞噬指数明显高于阴性对照组。结论番茄红素能够增强小鼠细胞免疫和体液免疫功能。
作者 杜宏举 郑珊 马玲 张鹏 聂燕敏
机构地区 北京市预防医学研究中心/北京市疾病预防控制中心
出处 《毒理学杂志》 CAS CSCD 北大核心 2014年第3期211-214,共4页 Journal of Toxicology
关键词 番茄红素 免疫功能 小鼠
分类号 R114 [医药卫生—卫生毒理学]
作者简介 杜宏举，硕士，主管医师，研究方向：卫生毒理学。
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参考文献17

  • 1Liu C, Russell RM, Wang XD. Lycopene supplementation prevents smoke-induced changes in p53,p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa ferrets [J]. J Nutr, 2006, 136(1) : 106-111.
  • 2Yang CM, Yen YT, Huang CS, et al. Growth inhibitory efficacy of lycopene and p-carotene against androgen- independent prostate tumor cells xenografted in nude mice [J].MolNutrFood Res, 2011, 55(4): 606-612.
  • 3Reid K, Fakler P. Protective effect of lycopene on serum cholesterol and blood pressure : Meta-analyses of intervention trials [J]. Maturitas, 2011, 68(4): 299-310.
  • 4Nkondjock A, Ghadirian P, Johnson KC, et al. Dietary intake of lycopene is associated witll reduced pancreatic cancer risk[J]. J Nutr, 2005, 135(3): 592-597.
  • 5Watzl B, Bub A. Prolonged tomato juice consumption has no effect on cell-mediated immunity of well nourished elderly men and women[J]. J Nutr, 2000, 130 (7): 1719-1723.
  • 6潘洪志,那立欣,石刚,李省三,王德才,曹军.番茄红素对大鼠细胞DNA氧化损伤修复的影响[J].卫生研究,2004,33(2):189-191. 被引量：18
  • 7袁暾,魏大鹏,廖林川,王霞,蔡美英.番茄红素对非特异性免疫功能的体外实验研究[J].食品科学,2003,24(4):133-136. 被引量：18
  • 8Briviba K, Kulling SE, Moseneder J, et al. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions smokers[ J]. Carcinogenesis, in healthy non-smokers and 2004, 25(12): 2373-2378.
  • 9Watzl B, Bub A, Briviba K, et al. Supplementation of a low-carotenoid diet with tomato or carrot juice modulates immune functions in healthy men [ J]. Ann Nutr Metab, 2003, 47(6) : 255-261.
  • 10Corridan BM, O' Donoghue M, Hughes DA, et al. Low does supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in health free-living elderly humans[J]. Eur J Clin Nutr, 2001, 55(8) : 627-635.

二级参考文献23

  • 1Simpson K L. Biochemical methodology for the assessment of carotenes. A report oflVACG. Washington, DC, 1987.46.
  • 2Ribeiro- Dias F, Russo M, Nascimento FR et al. Thioglycollate- elicited murine macrophages are cytotoxic to Mycoplasma arginini - infected YAC - 1 tumor cells[J] . Braz J Med Biol Res, 1998, 31 ( 11 ): 1425 - 1428.
  • 3Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability[J] . J Immunol Methods, 1986 , 22; 89(2): 271 - 277.
  • 4Wang YP, Li XY, Song CQ et al, Effect of astragaloside IV on T, B lymphocyte proliferation and peritoneal macrophage function in mice[J] . Acta Pharmacol Sin, 2002, 23(3):263 - 266.
  • 5Holt P S, Buckley S, Deloach J R. Detection of the lethal effects of T- 2 mycotoxin on cells using a rapid colorimetric viability assay[J]. Toxicol Lett, 987, 39(2 - 3): 301 - 12.
  • 6Di Mascio P, Devasagayam T P, Kaiser S et al. Carotenoids,tocopherols and thiols as biological singlet molecular oxygen quenchers[J] . Biochem Soc Trans, 1990 Dec, 18(6):1054- 1056.
  • 7Woodall AA, Lee SW, Weesie R Jet al. Oxidation of carotenoids by free radicals: relationship between structure and reastivity[J] . Biochim Biophys Acta, 1997, Jul 19,1336(1): 33-42.
  • 8Dipartimento di Gerontologia, Geriatria e Malattie del Metabolismo, Seconda Universita di Napoli. Dietary antioxidants for cardiovascular prevention[J]. Nutr Metab Cardiovasc Dis, 2000 Feb: 10(1): 38-44.
  • 9Riso P, Pinder A, Santangelo A et al, Does tomato consumption effectively increase the resistance of lymphocyte DNA to oxidative damage? [J]. Am J Clin Nutr, 1999, 69(4): 712-718.
  • 10Watzl B, Bub A, Brandstetter BR et al. Modulation of human T - lymphocyte functions by the consumption of carotenoid -rich Vegetables[J]. Br J Nutr, 1999, 82(5): 383 -389.

共引文献34

同被引文献147

引证文献21

二级引证文献87

毒理学杂志
2014年 第3期

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