摘要
信号转导是各类信号通过细胞膜或胞内信使分子引起细胞基因表达改变的过程。因此,当细胞信号转导过程发生障碍或异常,必然会导致细胞生长、分化、代谢及生物学特征异常,从而引起各种疾病甚至肿瘤的发生。目前已知与肺癌相关的细胞信号转导通路有Wnt、Notch、酪氨酸激酶和Hedgehog信号转导通路。现将近年来的研究进展作一综述。
Signal transduction is a process causing changes of gene expression in cells by signals through the cell membrane or intracellular messenger molecule. Therefore,cell signal transduction disorder or abnormality,will inevitably lead to cell growth,differentiation,metabolism and biological abnormalities,resulting in various diseases and even cancer. The cell signal transduction pathways associated with lung cancer include Wnt,Notch,tyrosine kinase and Hedgehog signal transduction pathway. This article makes a review on recent research.
出处
《临床肿瘤学杂志》
CAS
2014年第6期564-568,共5页
Chinese Clinical Oncology
关键词
肺癌
细胞信号转导通路
分子靶向治疗
Lung cancer
Cell signal transduction pathway
Molecule targeted therapy
