摘要
目的 研究甘氨双唑钠 (CMNa)的单剂量和多剂量药代动力学 ,以评价CMNa的蓄积性。方法 5名肿瘤病人 ,单次或每隔 1d连续 9次静脉滴注 70 0mg·m- 2 的CMNa液 ,分别在单次和第 9次静滴后设定时间点采血 ,用高效液相色谱 二极管阵列紫外法测定受试病人全血CMNa及其代谢产物甲硝唑浓度 ,对CMNa的血药浓度 时间数据进行了拟合 ,并对单剂量和多剂量的血药浓度 时间数据和药代动力学参数以及尿排泄率进行比较。结果 CMNa在病人体内分布及消除都很快 ,单剂量和多剂量静滴CMNa后血药浓度值和各药代动力学参数非常相近 ,没有明显差别。结论 甘氨双唑钠不会在肿瘤病人体内蓄积。
AIM To study the pharmacokinetics of the new tumor radiosensitizer glycodidazolum natrium(CMNa) in tumor patients after single and multiple dose, in order to evaluate the accumulation of CMNa in patients. METHODS Five tumor patients, were administered 700 mg·m -2 CMNa iv single dose or 9 times every other day, and blood samples were collected at designed time after single dose and the ninth CMNa administration, and we determined the blood concentration of CMNa and its metabolite metronidazole by high performance liquid chromatography ultraviolet. The CMNa blood concentration time data after single dose and multiple dose were simulated by computer software, and they fit linear open two departments model. The CMNa concentration time data, pharmacokinetic parameters and elimination rate in urine between single dose and multiple dose were compared. RESULTS CMNa distributed and eliminated rapidly in patients, their concentration time and pharmacokinetics parameters and elimination rate between single dose and multiple dose were similar with each other, and they have no significant difference. CONCLUSION CMNa will not accumulate in patients′ bodies, and it is a safe drug.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2002年第3期223-225,共3页
Chinese Journal of Pharmacology and Toxicology
