摘要
在慢性实验条件下观察到大鼠由学习训练所产生的海马CA_3区习得性长时程突触增强,它的不同发展阶段对新学习任务的习得有不同的作用:(1)在它的形成阶段及巩固阶段对新学习均有易化作用,虽然两个阶段突触效应增强的程度都处于相同的高水平,但后者的易化作用相对要大些,提示这两个发展阶段突触的可塑性变化是有差异的;还有,新学习任务的训练并没有引起突触效应的进一步增强,表明突触效应的长时程增强有“饱和”现象。(2)在它消退后,对新学习任务的习得没有影响。上述结果提示学习的组织形式不同,可从突触机制上影响学习的效果,并进一步证明习得性长时程突触增强是学习和记忆的神经基础。
The effects of learning-dependent long-term potentiation (LTP) in di-fferent development phases on the learning was investigated in freely mo-ving rats. The results showed: the acquisition of new conditional responsewas facilitated by the learning-dependent LTP in both the formation pha-se and consolidation phase, appeared with the former conditioning in thehippocampal CA3 region, but the facilitated effect of learning-dependentLTP in the consolidation phase is a little larger than in the formation ph-ase. As the learning-dependent LTP was extincted, no facilitated effecton the new learning appeared. However, the enhanced population spike(PS) did not increase further during the establishment of the new condi-tioning. Therefore, it is suggested that there might be some different chan-ges in synaptic plasticity at the different development phase of learning-dependent LTP and a 'saturated' phenomenon in the synaptic potentia-tion produced by behavioural training. These results support further thatlearning-dependent LTP might be one of the neuronal mechanisms under-lying behavioral learning and memory.
出处
《心理学报》
CSSCI
CSCD
北大核心
1991年第4期426-432,共7页
Acta Psychologica Sinica
基金
国家自然科学基金
