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氟比洛芬酯复合舒芬太尼在颌面外科术后镇痛效果的临床研究 被引量:10

Post-operation analgesic effects of flurbiprofen compound with sufentanil after maxillofacial surgery
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摘要 目的:分析不同剂量氟比洛芬酯及复合其它镇痛药物在颌面外科加速康复外科中术后镇痛的效果。方法:纳入颌骨囊肿、多生阻生齿患者98例,按术后不同自控型输注泵(PCA)镇痛方案,将其分为Ⅰ组(n=32):氟比洛芬酯250 mg+0. 9%生理盐水(NS)至100 ml;Ⅱ组(n=34):舒芬太尼100μg+阿扎司琼20 mg+0. 9%NS至100 ml;Ⅲ组(n=32):氟比洛芬酯200 mg+舒芬太尼50μg+阿扎司琼20 mg+0. 9%NS至100 ml。根据Wong-Baker面部表情量表和数字等级评定量表(NRS)分别于术前、术后3 h,术后第1天、术后第2天将镇痛效果及不良反应纳入统计,用问卷调查方式评价术后镇痛满意度观察术后镇痛效果。结果:镇痛有效率Ⅰ组:40. 62%,Ⅱ组:67. 65%,Ⅲ组:68. 75%。镇痛效果满意度:Ⅰ组:71. 87%,Ⅱ组:58. 82%,Ⅲ组:93. 75%,差异有统计学意义(P <0. 05)。结论:氟比洛芬酯复合舒芬太尼用于颌面外科颌骨囊肿、多生阻生齿术后镇痛效果确切,且不良反应小。 Objective: To analyze the effects of different doses of flurbiprofen and other analgesic drugs on the postoperative analgesia in the Enhanced Recovery After Surgery( ERAS). Methods: 98 patients with jaw cysts or multiple impact teeth were retrospectively analyzed. Patients were divided into 3 groups by the drug scheme: flurbiprofen 250 mg + 0. 9% NS to 100 ml( group Ⅰ,n =32),sulfentanil 100 μg + azasetron 20 mg + 0. 9% NS to 100 ml( group Ⅱ,n = 34),flurbiprofen 200 mg + sulfentanil 50 μg + azasetron 20 mg + 0. 9% NS to 100 ml( group Ⅲ,n = 32). Analgesic effects were evaluated at 3 h,1 d and 2 d after surgery with Wong-Baker expression scale and numeric rating scale( NRS). Questionnaire survey was also used to evaluate degree of satisfaction on analgesia. Results: Analgesia effective rate of group Ⅰ,Ⅱ and Ⅲ was 40. 62%,67. 65% and 68. 75% respectively( P <0. 05). Degree of satisfaction on analgesia of group Ⅰ,Ⅱ and Ⅲ was 71. 87%,58. 82% and 93. 75% respectively( P < 0. 05).Conclusion: Flurbiprofen combined with sulfentanil has good analgesic effects and low side effects in the maxillofacial surgery of jaw cysts and multiple impact teeth.
作者 张铁成 葛慧 程菲 周永强 陈辉 刘桂才 ZHANG Tiecheng;GE Hui;CHENG Fei;ZHOU Yongqiang;CHEN Hui;LIU Guicai(Nantong Stomatological Hospital Department of Anesthesiology,China,226001)
出处 《实用口腔医学杂志》 CAS CSCD 北大核心 2019年第1期127-129,共3页 Journal of Practical Stomatology
关键词 氟比洛芬酯 舒芬太尼 术后镇痛 颌面外科 Furbiprofen Sulfentanil Postoperative analgesia Maxillofacial surgery
作者简介 通讯作者:刘桂才E-mail:lgcliuguicai@163.com.
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