摘要
双特异性抗体(bsAb)因可同时特异性结合2个不同抗原表位,拓展了治疗性单克隆抗体的临床应用范围。制备bsAb需要对传统的抗体结构进行改造,在此过程中衍生出了数十种结构,不同的结构具有不同的作用特点。本综述就当前典型的bsAb结构及其原理进行介绍,对bsAb的作用原理进行分析,并对当前代表性的bsAb的研发阶段进行了简单总结。
The clinical application of therapeutic monoclonal antibody has been extended by bispesific antibody(bsAb)due to their capacity of binding two different antigenic epitopes.Structure changing would be needed for the construction of bsAb.There are several tens of bsAb structures developed,the specific action characteristics of which are related with their unique bsAb structure.In this review,typical structures and acting principles of bsAb were introduced,the action principle of bsAb was analyzed,and the development stages of representative bsAb were briefly summarized.
作者
张峰
王开芹
王兰
ZHANG Feng;WANG Kai-qin;WANG Lan(Division of Monoclonal Antibody,National Institutes for Food and Drug Control,Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products,Beijing 102629,China)
出处
《药物分析杂志》
CAS
CSCD
北大核心
2019年第1期78-85,共8页
Chinese Journal of Pharmaceutical Analysis
作者简介
第一作者:张峰,Tel:(010)53852178;E-mail:zhangfeng5122@163.com;通信作者:王兰,Tel:(010)53852159;E-mail:wanglan@nifdc.org.cn.
