摘要
中药敷脐治疗肝硬化腹水是一种简便有效的特色疗法。该文借助中医传承辅助系统分析中药敷脐治疗肝硬化腹水的组方用药规律。通过检索中国知网、维普数据库、万方数据库近20年来中药敷脐治疗肝硬化腹水的文献为数据源,筛选并建立方剂数据库,运用频数统计、关联规则(Apriori法、复杂系统熵聚类)等进行数据挖掘,对核心药物及其归经、性味、组方规律、核心组合等进行分析研究。共筛选出治疗肝硬化腹水的敷脐方剂92首,涉及中药109种,分析出14个使用频次10及10以上的药物、19个常用药对,挖掘出12个核心药物组合。使用高频药物为甘遂、冰片、牵牛子、大黄、麝香、大戟、芒硝、肉桂、芫花、商陆等;归经以肺、脾、肾三经为主;药性以寒性药为主,药味以辛味药为主;常用药对为牵牛子-甘遂,冰片-甘遂,甘遂-大戟,甘遂-麝香,大黄-甘遂,甘遂-芫花,冰片-牵牛子,冰片-牵牛子-甘遂,甘遂-槟榔等;组方规律多以攻下逐水类药物为主,配伍通窍类、行气类、温阳类等药物。
Umbilicus application to treat ascites caused by cirrhosis is a simple and effective characteristic therapy. This article analyzed the regularity of application traditional Chinese medicine(TCM) herbs on umbilicus to treat ascites caused by cirrhosis through TCM inherited auxiliary system. This study chose academic literatures related to TCM dressing umbilicus to treat ascites caused by cirrhosis in CNKI database,VIP database,Wanfang database over the past 20 years as the data source,and established database to analyze the core drugs and their channel tropism,property and flavor,compatibility law,and core composition,by means of frequency statistics,and association rules(Apriori method,complicated system entropy clustering). Finally,92 prescription to treat ascites caused by cirrhosiss were screened out. These prescription includes 109 traditional Chinese medicines. And the analysis showed that there are14 drugs with usage frequency of 10 and more than 10,19 common drug pairs,12 core drug combination. The drugs with high usage frequency include Kansui Radix,Borneolum Syntheticum,Pharbitidis Semen,Rhei Radix et Rhizoma,Moschus,Euphorbiae Pekinensis Radix,Natrii Sulfas,Cinnamomi Cortex,Genkwa Flos,Phytolaccae Radix,Arecae Semen. And the channel which are mostly invoivet includ lung meridian,spleen meridian and kidney meridian;while the property and flavor of the herbs used have the properties of cold and acrid;the common drug pairs include Pharbitidis Semen-Kansui Radix,Borneolum Syntheticum-Kansui Radix,Kansui Radix-Euphorbiae Pekinensis Radix,Kansui Radix-Moschus,Rhei Radix et Rhizome-Kansui Radix,Kansui Radix-Genkwa Flos,Borneolum Syntheticum-Pharbitidis Semen,Borneolum Syntheticum-Pharbitidis Semen-Kansui Radix,Kansui Radix-Arecae Semen;herbs with the function of expelling water and purgation used as main conponents,and resuscitation,promoting the circulation of Qi,and increaseing Yang used as auxilizy conponents.
作者
代倩兰
江锋
王京
宫朝玲
史曼玉
DAI Qian-lan;JIANG Feng;WANG Jing;GONG Chao-ling;SHI Man-yu(Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing 100700,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2018年第22期4541-4546,共6页
China Journal of Chinese Materia Medica
基金
国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2012ZX10005009-005,2012ZX10005010-002-005)
北京市科委首都临床特色应用研究专项(Z151100004015161)
关键词
肝硬化腹水
敷脐疗法
中药
用药规律
中医传承辅助系统
ascites due to cirrhosis
umbilicus application
traditional Chinese medicine
medication rule
Chinese medicine inheritance auxiliary system
作者简介
代倩兰,硕士研究生,E-mail:185328815@qq.com;通信作者:江锋,博士,副主任医师,硕士生导师,研究方向为中医药防治脾胃病及慢性肝病,E-mail:jiangfengtcm@163.com.
