摘要
乳腺癌是女性发病率最高的恶性肿瘤,其发生发展是由多因素共同作用的结果。随着分子流行病学与基因组学的发展,遗传因素在乳腺癌发生发展中的作用得到了全新的认识。遗传性乳腺癌与乳腺癌易感基因(BRCA)具有显著的相关性,而散发性乳腺癌的遗传因素可从单核苷酸多态性(single nucleotide polymorphism,SNP)易感位点与表观遗传学方面进行分析。本文将对近年来对BRCA、SNP易感位点与表观遗传学的研究进展作一综述。
Breast cancer is the most common malignant tumor in women, The occurrence of breast cancer is caused by many factors.With the development of molecular epidemiology and genomics, there is a new understanding of the relationship between genetic factors and breast cancer. Hereditary breast cancer has a significant correlation with breast cancer predisposing gene (BRCA). The genetic factors of sporadic breast cancer can be analyzed from single nucleotide polymorphism (SNP) susceptibility loci and epigenetics. In this review, we will review the progress of BRCA and SNP susceptibility loci and epigenetics in recent years.
作者
付莉
王振宇
薛婷
姜晓曼
张颖超
Fu Li;Wang Zhenyu;Xue Ting;Jiang Xiaoman;Zhang Yingchao(Department of breast surgery,the Second Hospital of Jilin University,Changchun 130041 ,China)
出处
《国际遗传学杂志》
CAS
2018年第6期524-529,共6页
International Journal of Genetics
作者简介
通信作者:张颖超(E-mail:yingehaozhang770330@aliyun.com).
