摘要
氧化苦参碱对化学品、免疫和缺血再灌注性肝损伤均有肝保护作用。氧化苦参碱是通过抗氧化、抗炎作用上调血红素加氧酶-1表达,下调TRL4/p38/JNK信号通路,促进Bcl-2表达和抑制炎性细胞因子表达,从而抑制肝细胞凋亡,对多种原因引起的肝损伤均有保护作用。氧化苦参碱还可通过促进IL-27的分泌,抑制Th17细胞分化和IL-17A表达,以及促进调节性T细胞分化和IL-10表达,产生抗免疫性肝损伤作用。综述氧化苦参碱抗急性肝损伤的药理作用文献,并对其研究进展做了分析。
Oxyatrine has hepatoprotective activity against acute liver injuries induced by chemicals, immunity and ischemia/reperfusion. Protection of matrine against manifold causes-induced liver injuries is produced by anti-oxidation and anti-inflammation, up-regulating the expression of HO-1, and down-regulating signal pathway of TRL4/p38/JNK,and inducing the expression of Bcl-2, as well as inhibiting the expression of inflammatory cytokines,thus decreasing cell apoptosis. Oxymatrine hepatoprotective effect against immunity-induced liver injury was produced through improving secretion of IL-27,and inhibiting the differentiation of Th17 cells and the expression of IL-17 A, as well as improving the differentiation of Treg cells and the expression of IL-10. The literatures of pharmacological effects of oxymatrine on acute liver injury were reviewed and the research progress was analyzed. 87944X 2018,(11):1845-1849
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2018年第11期1841-1844,共4页
Anti-infection Pharmacy
关键词
氧化苦参碱
肝保护作用
急性肝损伤
化学品性肝损伤
免疫性肝损伤
缺血再灌注性肝损伤
oxymatrine
hepatoprotection
acute liver injury
chemicals-induced liver injury
immunity-induced liver injury
ischemia/reperfusion-induced liver injury
作者简介
张明发(1946-),男,研究员.联系电话:13816371915.E-mail:13816371915@139.com.
