摘要
氧化苦参碱能防治二乙基亚硝胺或2-乙酰氨基芴诱发大鼠原发性肝癌和小鼠肝癌H22细胞移植瘤在小鼠体内的生长。体外研究发现氧化苦参碱能浓度相关地抑制肝癌HepG2细胞、SMMC-7721细胞、BEL-7402细胞、BEL-7404细胞、QGY细胞、QGY-7703细胞、97H细胞的增殖并诱导其凋亡,还可能诱导HepG2细胞、BEL-7402细胞、PLC/PRF/5细胞的分化,也能提高荷瘤机体的免疫调节功能。综述氧化苦参碱抗肝癌作用及机制的药理作用文献,并对其研究进展做了分析。
Oxymatrine has the effects in the prophylaxis and treatment of rat hepatoma induced by diethylnitrosamine or 2-acetaminofluorene, and also has the effect of the inhibiting growth of murine hepatocarcinoma cell H22 transplantation tumor in mice. Oxymatrine inhibits proliferation, and induces apoptosis in association with dosage on hepatoma HepG2 cells,SMMC-7721 cells, BEL-7702 cells, BEL-7704 cells, QGY cells, QGY-7703 cells and 97 H cells. Oxymatrine induces differentiation in hepatoma HepG2 cells, BEL-7404 cells, and PLC/PRF/5 cells too. Oxymatrine also elevates immunoregulative function in tumor-bearing body. The pharmacological effects of oxymatrine on hepatocellular carcinoma and its mechanism were reviewed and its research progress was analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd,Shanghai 201204,China)
出处
《抗感染药学》
2019年第11期1841-1846,共6页
Anti-infection Pharmacy
关键词
氧化苦参碱
肿瘤细胞
肝癌
药理作用
作用机制
oxymatrine
hepatocellular carcinoma
hepatoma
pharmacological effects
mechanism
作者简介
张明发(1946-),男,研究员【联系电话】:13816371915,E-mail:13816371915@139.com。
