摘要
目的探讨GPI、抗-CCP和RF联合检测对类风湿关节炎的临床意义。方法选择本院就诊的143例RA患者作为观察组,选取同期本院其他自身免疫性疾病患者130例及健康体检者160例作为对照组。采集观察组及对照组空腹静脉血,检测血清RF、抗-CCP及GPI水平。结果单一标志物检测中敏感度最高的是RF(81.82%),特异度最高的是抗-CCP(92.11%),阳性预测值最高的是抗-CCP(87.80%),阴性预测值最高的是RF(85.23%)。两项联合检测中敏感度最高的是抗-CCP+GPI(73.43%),特异度最高的是抗-CCP+GPI(94.74%),阳性预测值最高的是抗-CCP+GPI(91.30%),阴性预测值最高的是抗-CCP+GPI(82.57%)。三项联合检测敏感度是74.13%,特异度是94.21%,阳性预测值为90.43%,阴性预测值为82.87%。结论多项标志物联合检测能进一步提高特异性,诊断RA更准确,有助于治疗和判断预后,具有重要的临床意义。
Objective To explore the clinical significance of combined detection of GPI,anti -CCP and RF in diagnosis of rheumatoid arthritis.Methods Totally 143 patients with rheumatoid arthritis from our hospital were selected as observation group,130 patients with other autoimmune diseases and 160 healthy people at the same period were selected as control group. Fast vein blood samples were obtained from two groups,and the levels of GPI,anti -CCP and RF were detected.Results In the single marker detection,RF had the highest sensitivity for diagnosing RA (81.82%),anti -CCP had the highest specificity (92.11%).Anti-CCP had the highest positive predictive value (87.80%),RF had the highest negative predictive value (85.23%).In the two-marker detection,anti -CCP +GPI had the highest sensitivity (73.43%)and highest specificity (94.74%).Anti -CCP +GPI had the highest positive predictive value (91.30%)and the highest negative predictive value of diagnosis (82.57%).RF +anti -CCP +GPI had the sensitivity of 74.13%,specificity of 94.21%,positive predictive value of 90.43%,negative predictive value of 82.87%.Conclusion The combined detection of GPI,anti -CCP and RF can increase specificity and diagnosis more correctly,which is helpful for the treatment and predicting prognosis.It has important clinical significance.
作者
钟旭军
ZHONG Xu-jun(Department of Laboratory,the Second People's Hospital of Fuyang District,Hangzhou,Zhejiang 311404,China)
出处
《中国卫生检验杂志》
CAS
2018年第24期3019-3021,共3页
Chinese Journal of Health Laboratory Technology
关键词
类风湿关节炎
葡萄糖-6-磷酸异构酶
抗环瓜氨酸肽
Rheumatoid arthritis
Glucose-6-phosphate isomerase
Anti-cyclic citrullinated peptide antibody
作者简介
钟旭军(1971-),男,本科,副主任技师,主要从事临床检验工作。
