摘要
目的观察加味金粟丹对小儿高热惊厥的防治作用。方法将250例高热惊厥患儿分为治疗组(180例)与对照组(70例)。对照组发作期予常规西药治疗,缓解期不予干预。治疗组发作期西药治疗结束2周后服用加味金粟丹。两组疗程均为2个半月、随访1年,观察综合疗效,比较高热惊厥的复发率、最低惊厥体温及脑电图异常率的情况。结果 (1)最终完成试验者228例,其中治疗组165例,对照组63例。(2)治疗组、对照组有效率分别为69.7%、54.0%;组间综合疗效比较,差异有统计学意义,治疗组明显优于对照组(P<0.05)。(3)组间惊厥复发率比较,差异有统计学意义,治疗组明显低于对照组(P<0.05)。(4)再次发生惊厥的患儿中,随访期间与治疗前组内比较,两组最低惊厥体温差异均有统计学意义,均明显升高(P<0.05);但组间最低惊厥体温比较,差异无统计学意义(P>0.05)。(5)随访1年后,治疗组、对照组的脑电图异常率分别为9.5%、21.3%,组间脑电图异常率比较差异有统计学意义,治疗组明显低于对照组(P<0.05)。结论加味金粟丹对于小儿高热惊厥的复发具有一定的预防作用,且对高热惊厥所致脑部损伤有一定的预防作用。
Objective To observe the preventive and therapeutic effects of Modified Jinsu Pill on pediatric febrile convulsion (FC) . Methods 250 children patients with febrile convulsion were randomly divided into the treatment group (180 cases) and control group (70 cases) . The control group was treated with routine western medicine in acute stage and no intervention in remission stage,the treatment group was treated with Modified Jinsu Pill two weeks after the therapy of routine western medicine in acute stage,with a treatment course of 2.5 months and follow-up of 1 year. The comprehensive efficacy was observed. The recurrence rate of febrile convulsion,the lowest temperature inducing FC and the abnormity rate of encephalogram (ECG) were compared. Results ①Finally 228 cases completed the trial,among 165 cases in the treatment group and 63 cases in the control group. ②The effective rates were 69.7% in the treatment group and 54.0% in the control group. The comprehensive efficacy of the treatment group was better than that of the control group,with statistically significant difference (P<0.05) . ③The recurrence rate of convulsion in the treatment group was obviously lower than that in the control group,with statistically significant difference (P<0.05) . ④ Among the patients with recurrence convulsion,compared between treatment before and follow-up,there was statistically significant difference on the lowest temperature inducing FC in both groups,and the temperature was obviously increased in both groups (P<0.05) . However,during the follow-up,there was no statistically significant difference on the lowest temperature inducing FC between the two groups (P>0.05) . ⑤After follow-up for one year,the abnormity rates of ECG were 9.5% in the treatment group and 21.3% in the control group,the abnormity rate of ECG of the treatment group was obviously lower than that of the control group,with statistically significant difference (P<0.05) . Conclusion Modified Jinsu Pill exerts certain preventive effects on the recurrence of pediatric febrile convulsion,as well as the brain damage induced by febrile convulsion.
作者
郭大畅
李战
倪菊秀
顾申枫
许莉
沈佳颖
GUO Dachang;LI Zhan;NI Juxiu;GU Shenfeng;XU Li;SHEN Jiaying(Department of Chinese Medical Pediatrics,Central Hospital of Jing'an District ( Jing'an Branch of Huashan Hospital Affiliated to Fudan University),Shanghai 200040,China)
出处
《上海中医药杂志》
2018年第12期59-61,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市卫计委基层名老中医专家传承研究工作室建设项目(JCZYGZS-021)
上海市静安区卫计委进一步加快中医药事业发展三年行动计划项目(JA2015-C002)
上海市静安区卫计委师承培养项目(2016年-2018年)
关键词
高热惊厥
小儿
加味金粟丹
复发率
最低惊厥体温
脑电图
癫痫
febrile convulsion
pediatric
Modified Jinsu Pill
recurrence rate
lowest temperature inducing febrile convulsion
encephalogram
epilepsy
作者简介
郭大畅,男,副主任医师,主要从事中医、针灸的临床和研究;通信作者:李战,副主任医师。E-mail:lizhanzhan1976@ 163.com
