摘要
[目的]观察补阳还五汤联合倍他司汀治疗后循环缺血性眩晕(气虚血瘀)疗效。[方法]使用随机平行对照方法,将80例住院患者按随机数字表法随机分为两组。对照组40例,倍他司汀,12mg/次,3次/d,口服。治疗组40例,补阳还五汤(黄芪生60g,当归15g,赤芍、川芎、桃仁各10g,红花、地龙各6g),水煎400mL,1剂/d,早晚温服200mL;兼肝阳上亢加天麻、钩藤、黄芩各10g;兼风痰瘀阻加半夏制、南星制、白僵蚕各10g;兼肾精不足加首乌制、黄精各10g,枸杞子15g;兼血亏络滞加丹参、地黄熟、鬼箭羽各10g;倍他司汀治疗同对照组。连续治疗4周为1疗程。观测临床表现、眩晕症状评分、血液流变学、血脂、中医证候积分、不良反应。治疗1疗程(4周),判定疗效。[结果]治疗组治愈17例,显效15例,有效5例,无效3例,总有效率92.50%;对照组治愈13例,显效7例,有效12例,无效8例,总有效率80.00%;治疗组疗效优于对照组(P<0.05)。眩晕症状评分两组均有降低(P<0.01),治疗组降低多于对照组(P<0.05,P<0.01)。TC、TG、HDL-C、LDL-C两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。WBV(H)、WBV(M)、WBV(L)、PV、FIB两组均有改善(P<0.05,P<0.01),治疗组改善优于对照组(P<0.05,P<0.01)。中医证候积分两组均有降低(P<0.01),治疗组降低多于对照组(P<0.01)。[结论]补阳还五汤联合倍他司汀治疗后循环缺血性眩晕(气虚血瘀),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the effect of Buyang Huanhe decoction combined with betahistine in the treatment of posterior circulation ischemic vertigo(Qi deficiency and blood stasis).[Method] 80 hospitalized patients were randomly divided into two groups according to random number table Using randomized parallel control methods,40 cases in the control group,betahistine,12 mg/times,3 times/d,po.40 cases in treatment group,BuYang Huanwu decoction(Shenghuangqi 60 g,Danggui 15 g,Chishao,Chuanxiong,Taoreneach 10 g,Honghua,Dilong each 10 g,add water and cook to 400 mL,1 doses/d,take 200 mL in the morning and evening.Hyperactivity of liver Yang add Tianma,Gouteng,Huangqin each 10 g.Wind phlegm and Blood stasis add Zhiban xia,Zhi nanxing,Jiangcan each 10 g.Deficiency of kidney-essence add Zhishouwu,Huangjing each 10 g,Gouqi 15 g.Blood loss and collaterals stagnation add Danshen,Shudi,Guijianyu each 10 g,the dose of betahistine was the same as that of the control group.One courses is continuous treatment for 4 weeks.Observation of clinical manifestations,vertigo symptom score,hemorheology,blood fat,TCM syndrome score and adverse reaction.Judge the curative effect after one courses of treatment(4 weeks).[Results] 17 were cured,15 of obvious effect,5 effective and 3 failed in the treatment group,The total effective rate is 92.50%.13 were cured,7 of obvious effect,12 effective and 8 failed in the control group,The total effective rate is 80.0%.The curative effect of the treatment group was better than that of the control group(P<0.05).Dizziness symptom scores were reduced in the two groups(P<0.01),The treatment group decreased more than the control group(P<0.05,P<0.01).The two groups of TC,TG,HDL-C and LDL-C were improved(P<0.05,P<0.01).The treatment group improved better than the control group(P<0.05,P<0.01).WBV(H),WBV(M),WBV(L),PV and FIB improved in two groups(P<0.05,P<0.01).The treatment group improved better than the control group(P<0.05,P<0.01).TCM syndrome scores in the two groups were decreased(P<0.01).The treatment group decreased more than the control group(P<0.01).[Conclusion] Buyang huanwu decoction combined with betahistine in the treatment of posterior circulation ischemic vertigo(Qi deficiency and Blood stasis) is satisfactory and no serious adverse reactions were worthy of promotion.
作者
江雯涵
JIANG Wenhan(Department of Eneephalopathy,Taieang Hospital of Traditional Chinese Medicine/Department of Eneephalopathy,Taieang Hospital Affiliated to Nanjing University of Chinese Medicine,Taicang 1215400,Jiangsu,China)
出处
《实用中医内科杂志》
2018年第10期38-42,共5页
Journal of Practical Traditional Chinese Internal Medicine
基金
太仓市科技计划项目(TC2016SFYL05)~~
