摘要
目的 比较不同方案治疗小儿消化性溃疡的疗效和幽门螺杆菌 (Hp)根除率 ,并随访 2年 ,以评价Hp在小儿消化性溃疡愈合和复发中的作用。方法 1 1 3例Hp感染伴消化性溃疡患儿分 4组接受治疗。A组奥美拉唑 0 8mg/(kg·d)顿服 ,疗程 2周 ;B组西咪替丁 1 5mg/(kg·d)或雷尼替丁 5mg/(kg·d) ,每日分 2次口服 ;C组胶体枸橼酸铋 8mg/(kg·d) ,每日分 3次口服 ;D组硫糖铝 2 5mg/(kg·d) ,每日分 4次口服。上述各组同时加服阿莫西林 50mg/(kg·d)和甲硝唑 1 5mg/(kg·d) ,均分 3次口服 ;B、C和D组疗程均 4周。 结果 ①溃疡治愈率 :A组 96% ( 46/4 8) ,B组 81 % ( 2 6/3 2 ) ,C组 85% ( 1 7/2 0 ) ,D组 69% ( 9/1 3 ) ;Hp根除率 :A组 85% ( 41 /4 8) ,B组 53 %( 1 7/3 2 ) ,C组 75% ( 1 5/2 0 ) ,D组 3 8% ( 5/1 3 )。②Hp根除者溃疡愈合率 1 0 0 % ,未根除者愈合率 57% ,差异有显著性 (P <0 0 1 )。③随访发现Hp未根除者溃疡复发率 60 % ,反之根除者仅 4 %。 结论 根除Hp可以提高小儿消化性溃疡愈合率 ,降低溃疡复发率。质子泵抑制剂奥美拉唑加二联抗生素治疗小儿Hp感染的消化性溃疡具有疗效高的特点。
Objectives To observe the effect of different therapy in the management of peptic ulcer and the eradicative rate Helicobacter pylori(Hp)following the therapy.Methods\ 113 patients with pediatric Hp peptic ulcer were diveded into 4 groups.Group A was treated with Ome 0 8mg/(kg·d) for 2 weeks,group B with cimetidine 15mg/(kg·d)for 4 weeks,group C with CBS 8mg/(kg·d) for 4 weeks and group D with sucralfate 25mg/(kg·d) for 4 weeks.Amoxycillin 50mg/(kg·d) and metronidazol were administered to all the groups.Results\ (1)90%(46/48)of peptic ulcer in group A,81%(26/32)in group B,85%(17/20)in group C and 69%(9/13)in group D were cured.85%(41/48)of Hp in group A,53%(17/32)in group B,75%(15/20)in group C and 38%(5/13)in group D were eradicated.(2)100% of the peptic ulcer were cured in patients Hp eradicated,while 57% in uneradicated.(3)The recurrence rate was 65% in uneradicated group,while 4% eradicated group.Conclusions\ H.pylori eradication can improve the pediatric peptic cure rate and decrease the recurrence rate. Proton pump inhibitor(Ome) in combination with antibiotics showed more efficient therapeutic effect.
出处
《中国实用儿科杂志》
CSCD
北大核心
2001年第8期464-466,共3页
Chinese Journal of Practical Pediatrics
