摘要
提出了在 Lipasefrom Candida Antrarctica( CAL)脂肪酶的催化作用下 ,含有手性中心 C原子的胺类化合物酰胺化的异构选择性规则 .与氨基相连的碳原子的立体结构对酰胺化反应有很大的影响 . 型胺类化合物呈 R-型优先选择 , 型胺类化合物呈 S-型优先选择 .
An empirical rule for amidation of amines which contains chiral carbon catalyzed by lipase from candida antrarctica has been proposed, and it is the same one as alcohols. It can be used to predict that which enantiomer reacts faster based on the relative sizes of the substituents at the stereocenter, but the recognization is very delicate to the structure of the carbon contacted with amino group. The R enantiomer reacts faster when the amines are secondary amines; the S enantiomer reacts faster when they are primary amines.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2001年第8期1332-1337,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金 (批准号 :2 9775 0 12 )
山东省青年科学基金 (批准号 :Q 99B16 )
