摘要
目的 研究大肠癌患者血清糖链抗原CA5 0表达水平及其临床意义。方法 采用免疫放射分析法 (IR MA)对 73名正常人 ,3 3例大肠良性疾病及 13 6例大肠癌患者进行了血清CA5 0水平测定 ,同时用ELISA法测定了大肠癌患者血清CEA水平。结果 大肠癌患者血清CA5 0水平 (41.6± 3 0 .9u/ml)显著高于正常人 (8.9± 5 .5u/ml,P <0 .0 1)及良性疾病组 (11.2± 7.6u/ml ,P <0 .0 1)。以 2 0u/ml为阳性界值 ,CA5 0对诊断大肠癌的灵敏度为 72 .1% ,特异性为91.5 % ,有效率 82 .8%。血清CA5 0水平升高与大肠癌临床分期、复发和转移等因素密切相关。大肠癌患者血清CA5 0与CEA水平呈正相关 (r =0 .5 8,P <0 .0 1)。结论 CA5 0可作为大肠癌诊断和临床分期的辅助指标之一 ,有助于鉴别大肠疾病的良恶性 ,对病情变化。
Objective To study on expression and clinical application of serum carbohydrate antigen CA50 of patients with colorectal cancer.Methods The serum CA50 levels were determined by immunoradiometric assay (IRMA) in 73 healthy adults、33 patients with benign colorectal disease and 136 patients with colorectal cancer,and serum CEA levels were determined by ELISA in patietns with colorectal cancer.Results The serum CA50 levels of patients with colorectal cancer (41.6±30.9u/ml) were significantly higher than those of healthy adults (8.9±5.5u/ml,P<0.01) and patients with benign disease (11.2±7.6u/ml,P<0.01).when 20u/ml was positive limit,the positive rate,specificity and efficiency for colorectal cancer was 72.1%、91.5% and 82.8%,respectively.The increase of serum CA50 levels was related with the clinical stage,recurrence and metastasis of colorectal cancer.Serum CA50 levels was positively correlated with those of CEA.Conclusions It is suggested that CA50 may be considered as one of the indicators in diagnosis and classification of the clinical stage of colorectal cancer,and values of serumal CA50 may be helpful for estimating the development of disease and prognosis for patients with colorectal cancer. [
出处
《中国肿瘤临床与康复》
2001年第1期1-2,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
糖链抗原CA50
大肠癌
免疫放射分析
carbohydrate antigen CA50
colorectal cancer
immunoradiometric assah
