摘要
目的:探讨常见组织学类型大肠癌中血管内皮生长因子(V EGF)的表达及意义。方法:应用组织芯片技术及免疫组织化学方法探测80例大肠癌及30例正常结肠黏膜中VEGF的表达情况。结果:此80例大肠癌和30例正常结肠黏膜中检测VEG F阳性率分别为68.8%和3.3%,两者比较差异显著(P<0.01);在不同组织学类型的大肠癌中,V EGF的表达无显著差异;在不同浸润程度的大肠癌中,V EG F的表达有显著差异(P<0.01);在淋巴结转移为阳性及阴性的2组大肠癌中V EGF表达有显著差异(P<0.01)。结论:V EG F在大肠癌的发生、发展中起着重要作用。
Objective： To study the expression and significance of VEGF in the common histological types of colorectal carcinoma. Methods： Using tissue chip technique and immunohistochemical methods,80 specimens of colorectal carcinoma patients and 30 specimens of normal colorectal mucosa were studied for detecting VEGF. Results： The positive rates of VEGF in colorectal carcinoma and in normal colorectal mucosa specimens were 68.8% and3.3% respectively （P 〈0.01）. The expression of VEGF were not related to histological types,but related to the infiltration degrees. The positive rates of VEGF in lymph nodal positive and negative were84.9% and 37.0% respectively （P 〈0.01）. Conclusion： The over expression of VEGF may play an important role in oncogenesis of colorectal carcinoma.
出处
《实用中西医结合临床》
2005年第6期7-8,共2页
Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine
基金
江西省卫生厅科研资助项目(编号:20043007)
