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不同时机放置左炔诺孕酮宫内缓释系统的临床观察 被引量:6

Insertion of levonorgestrel-releasing intrauterine system in different periods
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摘要 目的:探讨左炔诺孕酮宫内缓释系统(LNG-IUS)分别于人工流产后即刻、经期、经后放置的临床效果.方法:202例妇女分别在人工流产后即刻、经期1~7d、经后3~7d放置LNG-IfS,随访12个月,对其避孕效果、副反应、因症取出和续用率进行观察比较.结果:随访12个月3组均无妊娠和IUS脱落,续用率>92/百妇女年,3组差异无统计学意义(P>0.05);经期延长和不规则点滴出血为主要副反应,影响满意度和续用率.放置后6个月内人工流产组较早出现闭经,经期延长和不规则点滴出血发生率较经期组和经后组低(P<0.01),经期组与经后组差异无统计学意义(P>0.05),至放置后12个月经期延长和不规则点滴出血发生率均明显下降,3组无统计学差异(P>0.05).结论:放置LNG-IUS是安全可靠的长效避孕方法,人工流产后即刻、经期、经后3~7d均为适宜的放置时机,而即刻放置出血副反应少,满意度高,依从性好. Objective:To compare clinical effects of levonorgestrel-releasing intrauterine system (LNG-IUS) inserted immediately after induced abortion,during menstruation and after the menstrual period.Methods:Two hundred and two women were divided into 3 groups.Women in group Ⅰ underwent LNG-IUS insertion immediately after surgical abortion in group Ⅰ,during the menstrual period in group Ⅱ,and on 3-7 days after the menstruation in group Ⅲ.All the women were followed up for 12 months.The contraceptive effectiveness,side effects,removal rate for medical reasons and continuation rate were evaluated.Results:During 12 months of follow up,no pregnancy and LNG-IUS expulsion were found.The continuation rate was more than 92/100 women per year,and no statistical differences were found among 3 groups (P>0.05).The major side effects were menostaxis and irregular spotting,which influenced the satisfaction and continuation rates.Within 6 months,Women in group Ⅰ experienced menorrhea earlier,and menostaxis and vaginal irregular bleeding was less than those of the other two groups,showing statistical differences(P <0.01).While there were no significant differences in the incidence rates of menostaxis and vaginal irregular bleeding between group Ⅱ and group Ⅲ (9>0.05).The incidence rates of menostaxis and vaginal irregular bleeding declined obviously close to a year later,and no statistical differences were found among the three groups (P>0.05).Conclusion:LNG-IUS is considered to be a safe and reliable long-term contraceptive method due to a higher satisfaction and better compliance.It is suggested to insert LNG-IUS immediately after surgical abortion,during the menstrual period,and on 3 -7 days after the menstruation.
出处 《中国计划生育学杂志》 2014年第4期255-258,共4页 Chinese Journal of Family Planning
关键词 左炔诺孕酮宫内缓释系统 放置时机 避孕效果 副反应 Levonorgestrel-releasing intrauterine system Inserting time Contraception effectiveness Side effect
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