摘要
目的:探讨联合检测血清ANA、SMA、PANCA、LKM及SLA在诊断自身免疫性肝炎(AIH)中的临床意义。方法:对50例自身免疫性肝炎患者和50例其他类型肝炎患者,分别进行常规生化检测和自身抗体检测。常规生化检测项目包括血清胆红素(TBIL)和转氨酶(ALT)等,自身抗体检测项目包括抗核抗体(ANA),抗髓过氧化物酶抗体(PANCA),肝肾微粒体抗体(LKM)等。结果:经常规生化检测,两组血清胆红素TBIL与DBIL,转氨酶ALT与AST,白/球比,IgG,γ-谷氨酰转肽酶(γ-GT)等比较差异均无统计学意义(P>0.05)。经自身抗体检测,两组ANA和SMA检出例数比较差异均有统计学意义(P<0.05);但两组PANCA、LKM以及SLA检出例数比较差异均无统计学意义(P>0.05)。结论:联合检测血清ANA、SMA、PANCA、LKM及SLA对诊断自身免疫性肝炎具有重要的临床意义。
Objective：To explore the clinical significance of joint monitoring of ANA,SMA,PANCA,LKM and SLA in the diagnosis of autoimmune hepatitis（AIH）. Method：Fifty cases of patients with autoimmune hepatitis and 50 cases of other types of hepatitis patients were selected,gave all the patients routine biochemical tests and auto antibodies. The routine biochemical tests included serum bilirubin（TBIL）and alanine aminotransferase（ALT）etc. The auto antibodies included anti nuclear antibody（ANA）,anti myeloperoxidase antibody（PANCA）,liver kidney microsomal antibody（LKM） etc. Result：There were no significant difference between the two groups in the routine biochemical test results of TBIL and DBIL,ALT and AST,white/ball ratio,IgG,gamma glutamyl transpeptidase（γ-GT）（P〉0.05）. There were significant difference between the two groups in the auto antibodies test results of the number of detected cases in ANA and SMA（P〈0.05）;but there were no significant difference between the two groups in the auto antibodies test results of the number of detected cases in PANC,ALKM and SLA（P〉0.05）.Conclusion：Joint monitoring of ANA,SMA,PANCA,LKM and SLA are of great clinical significance in the diagnosis of autoimmune hepatitis（AIH）.
出处
《中国医学创新》
CAS
2014年第8期50-52,共3页
Medical Innovation of China
作者简介
通信作者：刘波颖
