摘要
目的:探讨LEEP联合人干扰素治疗宫颈上皮内瘤变(CIN)的效果。方法:将88例CIN患者分为观察组46例接受LEEP联合人干扰素治疗,对照组42例仅接受LEEP治疗;对两组患者治疗后随访12个月,随访两组患者疗效、术后并发症、乳头瘤病毒(HPV)-DNA阴转率、液基薄层细胞检测(TCT)情况。结果:观察组术前术后诊断符合率为91.30%(42/46),对照组为92.86%(39/42)。观察组术中、术后情况及术后并发症和对照组相比差异无统计学意义(P>0.05)。治疗后6个月时观察组治愈率高于对照组,而复发率低于对照组,两组差异有统计学意义(P<0.05);观察组阴转率为84.09%,高于对照组的59.52%,两组差异有统计学意义(P<0.05)。治疗后12个月时观察组治愈率、复发率和对照组接近,差异无统计学意义(P>0.05);观察组阴转率为91.30%,高于对照组的73.81%,两组差异有统计学意义(P<0.05)。治疗前两组TCT结果无明显差异,治疗后6、12个月时,观察组TCT情况皆优于对照组,两组差异有统计学意义(P<0.05)。结论:LEEP联合人干扰素治疗CIN伴发高危型HPV,可以提高治愈率、阴转率,减少术后复发,同时还可改善CIN病变程度。
Objective： To explore the effect of LEEP combined with human interferon in treatment of cervical intraepithelial neo plasia （CIN） . Methods： A total of 88 patients with CIN were divided into two groups ： 46 patients in observation group were treated with LEEP combined with interferon therapy, 42 patients in control group were treated with LEEP; the patients in the two groups were followed upfor 12 months after treatment; the curative effects, postoperative complications, negative conversion rate of HPV - DNA, TCT results in the two groups were followed up. Results： The coincidence ratesbetween before and after LEEP in observation group and control group were 91.30% （42/46） and 92. 86% （39/42）, respectively. There was no statistically significant difference in intraoperative situation, postoperative situation, and postoperative complications between observa tion group and control group （ P 〉 0.05 ） . At 6 months after treatment, the cure rate in observation group was higher than that in control group, and the recurrence rate in observation group was lower than that in control group, and the dfferences between the two groups was sta-tistically significant （P 〈 0. 05 ） . The negative conversion rate of HPV - DNA in observation group was 84. 09%, which was statistically significantly higher than that in control group （59. 52% ） （P 〈 0. 05 ） . At 12 months after treatment, there was no statistically significant difference in cure rate and recurrence rate between observation group and control group （ P 〉 0. 05 ） . The negative conversion rate of HPV - DNA in observation group was 91.30%, which was statistically significantly higher than that in control group （ 73.81% ） （ P 〈 0. 05 ） . There was no statistically significant difference in TCT results before treatment between the two groups, at 6 and 12 months after treatment, TCT results in observation group were statistically significantly better than those in control group （P 〈 0. 05 ） . Conclusion： LEEP com bined with interferon in treatment of CIN combined with high risk HPV may raise the cure rate and negative conversion rate, reduce postoper ative recurrence, and improve the degree of CIN.
出处
《中国妇幼保健》
CAS
北大核心
2014年第7期1126-1129,共4页
Maternal and Child Health Care of China
基金
广东省江门市科技局科研项目〔JK201019〕
关键词
宫颈上皮内瘤变
宫颈环形电切术
干扰素
人乳头瘤病毒
Cervical intraepithelial neoplasia
Loop eleotrosurgical excisional procedure
Interferon
Human papillomavirus
