摘要
目的:观察补虚平喘膏穴位敷贴对Ⅲ级和Ⅳ级慢性阻塞性肺疾病稳定期患者生活质量的影响。方法:101例分为对照组50例和治疗组51例,两组均吸入舒利迭,治疗组另用补虚平喘膏穴位敷贴,治疗12周,观察治疗前后患者生活质量、中医症状、BODE评分及CD3+、CD4+、CD8+、CD4+/CD8+的变化。结果:两组圣乔治呼吸问卷总积分、呼吸症状、活动能力及疾病影响均较治疗前改善(P<0.05),治疗组呼吸症状、活动能力及总分均低于对照组(P<0.05),疾病影响两组无显著性差异(P>0.05)。治疗组咳嗽、咯痰、气促等症状改善优于对照组(P<0.05)。两组BODE评分与治疗前比较均有好转(P<0.05),治疗组比对照组改善更显著(P<0.05)。治疗后治疗组CD3+、CD4+、CD4+/CD8+升高、CD8+降低,对照组CD4+/CD8+升高、CD8+降低,治疗组与对照组比较CD4+/CD8+升高更显著。结论:舒利迭联合补虚平喘膏穴位敷贴是Ⅲ级和Ⅳ级COPD稳定期患者有效的治疗方案,能改善COPD稳定期患者生活质量。
Objectives ： The study was to discuss about the effect of point application with ＂bu-xu-ping-chuan plaster＂ in quality of life with a diagnosis of III and IV grade stable COPD （ chronic obstructive pulmonary diseases ） .Methods ： We collected 101 out-patients which met the inclusion criteria： Fluticasone propionate, 500μg/salmeterol, 50ug combination （ SFC 500/50 ） （ n=50 ） or SFC500/50 and point application combination （ n=51 ） .They were both treated for 12 weeks. Quality of life and syndrome of traditional Chinese medicine, Predose and postdose CD3＋. CD4＋, CD8＋, CD4＋/CD8＋, BODE index score were compared.Results： After treatment, the scores of each pare and total scores were significantly decreased in both groups according to the SGRQ （ P〈0.05 ） .After treatment , the scores of respiratory symptoms , limitation of activity and the total scores in the treatment group was significantly lower than those in the control group according to the SGRQ （ P〈0.05 ） . there was no significantly difference in effect on disease between groups according to the SGRQ after the treatment （ P〉0.05 ） .The symptom improvement scores were significantly better in the control groups according to short of breath, cough and expectoration （ P〈0.05 ） .The BODE scores were significantly higher in both groups after treatment and also the treatment group were better than the control group （ P〈0.05 ） .treatment group significantly increased postdose CD4＋/CD8＋ compared with control group, it also increased postdose CD3＋, CD4＋, CD4＋/CD8＋ and reduced CD8＋ while the control group increased postdose CD4＋/CD8＋ and reduced CDs＋.Conclusion： We concluded that SFC 500/50 and point application combination increased cell immunity, decreased times of acute episode, achieved improvement in lung function and relieved better clinical symptom, could be a effective therapeutic regimen of III and IV grade stable COPD.
出处
《实用中医药杂志》
2014年第3期171-173,共3页
Journal of Practical Traditional Chinese Medicine
基金
福建省教育厅科技项目(JB09149)
关键词
慢性阻塞性肺疾病
补虚平喘膏
穴位敷贴
生活质量
COPD
bu-xu-ping-chuan plaster
point application
quality of life
syndrome of traditional Chinese medicine
作者简介
通讯作者
