摘要
[目的]研究杀菌剂氟喹唑的合成路线。[方法]以2-氨基-5-氟苯甲酸为初始原料,经"一锅法"缩合闭环、氯化,亲核取代反应,得到目标产物氟喹唑。[结果]在优化的反应条件下,反应总收率为67.1%(以2-氨基-5-氟苯甲酸计),纯度99%;产物结构经HPLC-MS、1H NMR确证。[结论]该路线条件温和,收率高,可以作为氟喹唑的一种有效合成方法在工业上进行推广应用。
[Aims] This article aims to study the synthetic route of fluquinconazole. [Methods] Fluquinconazole was obtained from 2-amino-5-fluorobenzoic acid through reactions of condensation and ring-closure by one-pot method, chlorination and nucleophilic substitution. [Results] Under the optimal reaction conditions, the total yield of fluquinconazole was 67.1% based on 2-amino-5-fluorobenzoic acid, the purity was 99%. The structure was confirmed by HPLC-MS, ＇H NMR. [Conclusions] This method can be used as an effective path to synthesize fluquinconazole in industrial scale for the advantages of mild reaction condition and high yield.
出处
《农药》
CAS
CSCD
北大核心
2014年第2期93-95,共3页
Agrochemicals
关键词
杀菌剂
氟喹唑
合成
fungicide
fluquinconazole
synthesis
作者简介
王广宇（1983—），男，江苏常州人，硕士，主要从事农药及中间体的合成工艺研究。E-maii：wgy055@aliyun．com。
