摘要
目的采用三维斑点追踪技术（3D-STI）测定不同构型原发性高血压（EH）患者的左室整体功能指数（GPI），并评价3D-STI相关参数与GPI的相关性。方法将入选的164例原发性高血压患者依照左室构型分型标准依次分为：左室正常构型组（LVN，67例）、左室向心性重构组（CCR，49例）、左室向心性肥厚组（CCH，28例）和左室离心性肥厚组（ECH，20例），并选择30例与患者组年龄、性别匹配的健康志愿者作为对照组。采用3D-STI获取各组左室收缩期整体三维应变及扭转参数，并计算收缩不同步指数（SDI）和GPI，比较各组参数间的差异，分析其与GPI的相关性。结果与正常对照组相比，原发性高血压患者各组GPI、左室整体纵向收缩峰值应变（GLS）、整体纵向收缩峰值面积应变（GAs）、整体纵向收缩峰值应变（GRS）和整体三维应变（G3DS）均明显减低，差异均具有统计学意义（P〈O．05）。而CCH组和ECH组的SDI高于对照组，差异亦具有统计学意义（P〈0．05）。多元逐步回归结果显示，GAS对GPI影响最大。结论基于3D-STI的GPI可较好地评价原发性高血压患者左室的整体活动及功能，具有一定的临床价值。
Objective To investigate the left ventricular （LV） performance in patients with essential hypertension（EH） by global performance index （GPI） based on three-dimensional speckle tracking imaging （3D-STI）. Methods A total of 164 EH patients were enrolled and divided into four subgroups according to LV configuration.. LV normal group （LVN, n = 67）, concentric cardiac remodeling group （CCR, n = 49）, concentric cardiac hypertrophy group （CCH, n = 28） and eccentric cardiac hypertrophy group （ECH, n = 20）. Thirty age and sex matched healthy volunteers were enrolled as controls. 3D-STI was performed to assess LV 3D global strain and LV torsion, then LV systolic dyssynchrony index （SDI） and global performance index （GPI） were calculated. Global strain parameters were investigated among the groups, and correlations with GPI were studied. Results GPI,global longitudinal strain（GLS） ,global area strain（GAS）, global radial strain（GRS） and global 313 strain（G3DS） in EH groups were respectively lower than those in the normal controls, and there were statistical differences among the respective parameters （P d0. 05, respectively）. SDI in group CCH and ECH were significantly higher than that in normal controls （ P 0. 05 , respectively）. In multivariate stepwise regression analysis, GAS was the most influential to GPI. Conclusions GPI based on 3D-STi may accurately reflect LV performance in patients with EH, and has potential applications in clinical practice.
出处
《中华超声影像学杂志》
CSCD
北大核心
2014年第1期1-6,共6页
Chinese Journal of Ultrasonography
基金
上海市浦东新区科技发展基金创新资金项目（PKJ2010-Y16）
上海市浦东新区心血管疾病学科群项目（PWZxkq2010-01）
关键词
超声心动描记术
高血压
心室功能
左
三维斑点追踪显像
Echocardiography
Hypertension~ Ventricular function, left~ Three-dimensional speckletracking imaging
作者简介
（韩勇，内蒙古医科大学在读研究生）
通信作者：陈明，Email：mingchen1283@vip．163．com
