摘要
目的 了解骨关节炎滑膜和软骨中转化生长因子 βⅠ类受体和转化生长因子 βⅡ类受体的分布及变化 ,探讨滑膜转化生长因子 β受体与骨关节炎发病和治疗的关系。 方法 应用免疫组织化学方法对 2 6例骨关节炎及 3例正常滑膜和软骨中转化生长因子βⅠ类受体和转化生长因子βⅡ类受体及转化生长因子 β1的分布和阳性程度进行观察。结果 全部骨关节炎患者滑膜和软骨标本转化生长因子 βⅠ类受体染色阳性 ,阳性细胞包括滑膜衬里细胞、滑膜下层血管内皮细胞、间质巨噬细胞和软骨细胞 ,阳性颗粒位于细胞浆中。转化生长因子 βⅡ类受体在骨关节炎滑膜和软骨中的分布部位和阳性程度与转化生长因子 βⅠ类受体相似。 结论 在OA滑膜和软骨中TGFβ的信号传递媒介尚丰富 ,对抑制炎症过程。
Objective The expression of transforming growth factor beta receptor Ⅰ (TGFβRⅠ) and transforming growth factor beta receptor Ⅱ (TGFβRⅡ) in the synovium and the articular cartilage of patients with osteoarthritis were studied,to explore the possible relationship between the transforming growth factor beta receptor and the pathogenesis and treatment of osteoarthritis.Method The distribution and positive levels of TGFβRⅠ,TGFβRⅡ and TGFβ 1 in the synovium and articular cartilage from 26 patients with osteoarthritis and 3 patients with trauma were studied,using Immunohistochemial methods.Results Immunohistochemical staining of TGFβRⅠ showed positive in all synovial samples in patients with osteoarthritis.The positive staining of TGFβRⅠ was found in most synovial lining cells,endotheliocyte and the macrophage in subsynovial layer with osteoarthritis,especially macrophage like synoviocyte.The positive particles were distributed in the cytoplasma.The distribution and staining levels of TGFβRⅡ in synovium and articular cartilage of patients with osteoarthritis were similar to those of TGFβRⅠ.Positive stainings for TGFβRⅠ, TGFβRⅡ and TGFβ 1 were found in over half of chondrocytes.Conclusion It is suggested that vehicles of signal trasmission of TGFβ are rich in the synovial membrane and cartilage.There is an important effect of TGFβ receptor on inhibiting inflammatory process and helping to repair local tissue.
出处
《中华风湿病学杂志》
CAS
CSCD
2000年第6期361-363,I010,共4页
Chinese Journal of Rheumatology
关键词
转化生长因子Β受体
骨关节炎
滑膜
软骨
Receptor,transforming growth factor beta
Osteoarthritis
Synovial membrane
Cartill
