摘要
调研了穿心莲系列注射剂不良反应的有关文献报道,分析了中药注射剂的安全性现状,并对检验类过敏反应的3种模型:体外细胞模型、啮齿类小动物模型以及大动物模型进行总结。穿心莲系列注射剂由于其起效快、作用强,在危重疾病急救及感染性疾病等的治疗上具有一定的优势。然而,近年来,随着中药注射剂在临床上的广泛应用,不良反应报道也逐渐增多,尤其是类过敏反应等安全性问题越来越突出,应建立敏感而可靠的检测模型和评价方法,才能从根本上解决中药注射剂的安全问题。
Chuanxinlian injections are special in the treatment of some acute diseases and infectious diseases because of their rapid effect and high efficiency.However,more adverse reactions of Chuanxinlian injections,especially anaphylactoid reactions,have been reported along with their wide use in clinic recently.And the concerns to the safety of Chuanxinlian injections are much more focused.On the basis of the Chinese journal full-text data base,literatures about the adverse effects of Chuanxinlian injections were searched and investigated.The safety state of injection of Chuanxinlian injections was analyzed,and three kinds of detection model to anaphylactoid reactions：in vitro cell model,animal model of wild rodents and big animal model were summarized.We hope that paper could supply any research ideas for solving the safety problems of traditional Chinese medicine injection.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第20期346-350,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广东省产学研重大专项(2010A090200076)
关键词
穿心莲注射剂
类过敏反应
不良反应
试验模型
Chuanxinlian injections
anaphylactoid reactions
adverse reactions
experimental models
作者简介
[第一作者]路新华，硕士，从事中药制剂研究与开发，Tel：13560214620，E—mail：kuailebaobei．lxh@163．com
[通讯作者]龙晓英，博士，教授，从事药物制剂新技术与新剂型的研究与开发，Tel：020-39352559，E-mail：longxy3156@163．com
